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Machina Carnis The Biochemistry of Muscular Contraction in its Historical Development 1st Edition by Dorothy Needham 0521112672 978-0521112673

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Machina Carnis The Biochemistry of Muscular Contraction in its Historical Development 1st Edition Dorothy M. Needham Digital Instant Download

Author(s): Dorothy M. Needham
ISBN(s): 9780521079747
Edition: 1
File Details: PDF, 30.60 MB
Year: 2009
Language: english
SKU: EB-2531010 Categories: , Tag:

Machina Carnis The Biochemistry of Muscular Contraction in its Historical Development 1st Edition by Dorothy Needham – Ebook PDF Instant Download/Delivery: 0521112672, 978-0521112673

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Product details:

ISBN 10: 0521112672

ISBN 13: 978-0521112673

Author: Dorothy M. Needham

Originally published in 1971, this is an account of the centuries of experiment and speculation that have led to our understanding of how muscles work. The book traces all the developments in the field since 1600 and devotes special attention to the breakthroughs made in the last century. It considers the nature of the muscle machine and its fuel, as well as the intricate regulation of energy supply under different conditions. It also examines the very varied kinds of muscle and the effects of some diseases on their structure and function. Finally it shows how the energy metabolism first elucidated for the mechanical work of muscle has been found to explain most of the other kinds of work done by cells, as in light production, secretion, ionic transport and electrical discharge. The biochemistry of muscle, carbohydrate metabolism and phosphorylations was the author’s chosen field of research for over forty years.

Table of contents:

  1. Bringing muscles into focus; the first two millennia

  2. Muscle metabolism after the Chemical Revolution; lactic acid takes the stage

  3. The relationship between mechanical events, heat production and metabolism; studies between 1840 and 1930

  4. The influence of brewing science on the study of muscle glycolysis; adenylic acid and the ammonia controversy

  5. The discovery of phosphagen and adenosinetriphosphate; contraction without lactic acid

  6. Adenosinetriphosphate as fuel and as phosphate-carrier

  7. Early studies of muscle structure and theories of contraction, 1870–1939

  8. Interaction of actomyosin and ATP

  9. Some theories of contraction mechanism, 1939 to 1956

  10. On myosin, actin and tropomyosin

  11. The sliding mechanism

  12. How does the sliding mechanism work?

  13. Excitation, excitation-contraction coupling and relaxation

  14. Happenings in intact muscle: the challenge of adenosinetriphosphate breakdown

  15. Rigor and the chemical changes responsible for its onset

  16. Respiration

  17. Oxidative phosphorylation

  18. The regulation of carbohydrate metabolism for energy supply to the muscle machine

  19. A comparative study of the striated muscle of vertebrates

  20. Enzymic and other effects of denervation, cross-innervation and repeated stimulation

  21. Some aspects of muscle disease

  22. Contraction in muscles of invertebrates

  23. Vertebrate smooth muscle

  24. Energy provision and contractile proteins in non-muscular functions

  25. The perspective surveyed

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Tags: Dorothy Needham, Machina, Biochemistry, Muscular