Medical Applications of Mass Spectrometry 1st Edition by Karoly Vekey, Andreas Telekes, Akos Vertes 9780444519801 0444519807

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Product details:

ISBN 10: 0444519807

ISBN 13: 9780444519801

Author: Karoly Vekey, Andreas Telekes, Akos Vertes

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities.
Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.

The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging.

* Provides a broad look at how the medical field is benefiting from advances in mass spectrometry.
* Guides the reader from basic principles and methods to cutting edge applications.
* There is NO comparable book on the market to fill this fast growing field.

Table of contents:

Part I: Motivation and Essentials
Chapter 1: Introduction
Chapter 2: Basics of analytical chemistry and mass spectrometry for medical professionals
Chapter 3: Ethical, legal, safety, and scientific aspects of medical research

Part II: Tools of the Trade
Chapter 4: Biomedical sampling
Chapter 5: Separation methods
Chapter 6: Mass spectrometry instrumentation and techniques
Chapter 7: Chemoinformatics – multivariate mathematical and statistical methods for data evaluation

Part III: Biomolecules
Chapter 8: Mass spectrometry in proteomics
Chapter 9: De novo sequencing of peptides
Chapter 10: Protein bioinformatics
Chapter 11: Analysis of complex lipidomes

Part IV: Selected Medical Applications
Chapter 12: Medical laboratory practice – possibilities for mass spectrometry
Chapter 13: Therapeutic drug monitoring and measurement of drug concentrations using mass spectrometry
Chapter 14: Mass spectrometry of infectious pathogens
Chapter 15: Proteomics of viruses
Chapter 16: Neonatal research
Chapter 17: Applications of mass spectrometry in oncology
Chapter 18: Application of mass spectrometry in brain research: neurotransmitters, neuropeptides, and more
Chapter 19: The human pituitary proteome: clinical applications
Chapter 20: Mass spectrometry of proteinous allergens inducing human diseases
Chapter 21: Mass spectrometry in clinical treatment

Part V: Emerging Areas
Chapter 22: Biomarker discovery
Chapter 23: Molecular imaging by mass spectrometry
Chapter 24: Brief outlook

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Tags: Karoly Vekey, Andreas Telekes, Akos Vertes, Medical