Medical therapy of breast cancer 1st Edition by Zenon Rayter, Janine Mansi ISBN 0511116241 9780511116247

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ISBN 10: 0511116241 
ISBN 13: 9780511116247
Author: Zenon Rayter, Janine Mansi

There have been very significant advances across many areas of the study, investigation and treatment of breast cancer. This publication surveys how scientific advances have influenced, improved and extended therapeutic options. The volume spans prevention, screening, genetics, and treatment of pre-invasive breast cancer, before focusing in depth on management of established breast cancer. This includes chapters on the various therapeutic options available and their role in treating breast cancer from the very earliest stage through to advanced and metastatic breast cancer. In addition, the text looks forward at the potential for emerging experimental strategies to become adopted into medical management in the future. The volume concludes with a chapter on palliative care. This wide-ranging account will be essential for breast cancer specialists, trainees in oncology and clinical research scientists.

Medical therapy of breast cancer 1st Table of contents:

Part I: Foundational Principles and Biology

• Chapter 1: Introduction to Breast Cancer
  • Epidemiology and Global Burden
  • Risk Factors and Prevention Strategies
  • Overview of Breast Cancer Subtypes
• Chapter 2: Molecular and Cellular Biology of Breast Cancer
  • Genetic Basis of Breast Cancer (e.g., BRCA1/2, HER2, ER/PR)
  • Signaling Pathways in Breast Cancer
  • Tumor Microenvironment
• Chapter 3: Pathology and Diagnosis
  • Histological Classification of Breast Cancer
  • Immunohistochemistry (IHC) and Molecular Profiling
  • Diagnostic Modalities (Imaging, Biopsy Techniques)
• Chapter 4: Staging and Prognostic Factors
  • TNM Staging System (AJCC)
  • Prognostic and Predictive Biomarkers
  • Recurrence Risk Assessment

Part II: Systemic Medical Therapies

• Chapter 5: Principles of Systemic Therapy
  • Goals of Therapy (Cure, Palliation, Adjuvant, Neoadjuvant)
  • Pharmacokinetics and Pharmacodynamics in Oncology
  • Managing Treatment-Related Toxicities
• Chapter 6: Endocrine Therapy for Hormone Receptor-Positive Breast Cancer
  • Mechanism of Action of Endocrine Agents (Tamoxifen, Aromatase Inhibitors, Fulvestrant)
  • Adjuvant and Neoadjuvant Endocrine Therapy
  • Therapy for Metastatic Hormone Receptor-Positive Breast Cancer
  • Management of Endocrine Resistance
• Chapter 7: Chemotherapy in Breast Cancer
  • Classes of Chemotherapeutic Agents (Anthracyclines, Taxanes, Alkylating Agents, Antimetabolites)
  • Adjuvant and Neoadjuvant Chemotherapy Regimens
  • Chemotherapy for Metastatic Breast Cancer
  • Managing Chemotherapy Side Effects
• Chapter 8: HER2-Targeted Therapy
  • HER2 Biology and Testing
  • Monoclonal Antibodies (Trastuzumab, Pertuzumab)
  • Antibody-Drug Conjugates (e.g., T-DM1, Trastuzumab Deruxtecan)
  • Tyrosine Kinase Inhibitors (Lapatinib, Neratinib)
  • Treatment Strategies for HER2-Positive Breast Cancer
• Chapter 9: Targeted Therapies for Other Subtypes
  • CDK4/6 Inhibitors for HR+/HER2- Breast Cancer
  • PARP Inhibitors for BRCA-Mutated Breast Cancer
  • PI3K/AKT/mTOR Pathway Inhibitors
  • Other Emerging Targeted Agents
• Chapter 10: Immunotherapy in Breast Cancer
  • Principles of Cancer Immunotherapy
  • Checkpoint Inhibitors (PD-1/PD-L1)
  • Current Role and Future Directions in Breast Cancer
• Chapter 11: Bisphosphonates and Denosumab in Breast Cancer
  • Management of Bone Metastases
  • Role in Adjuvant Setting

Part III: Treatment by Disease Stage and Specific Situations

• Chapter 12: Management of Early-Stage Breast Cancer
  • Treatment Paradigms for Stage I, II, and Operable Stage III
  • Adjuvant and Neoadjuvant Approaches
  • Local vs. Systemic Therapy Decisions
• Chapter 13: Management of Locally Advanced Breast Cancer
  • Neoadjuvant Therapy for Downstaging
  • Multidisciplinary Approach
  • Post-Neoadjuvant Treatment Strategies
• Chapter 14: Management of Metastatic Breast Cancer
  • Treatment Goals and Patient-Centered Care
  • First-Line and Subsequent-Line Therapies
  • Site-Specific Metastasis Management (Bone, Brain, Visceral)
  • Palliative Care and Symptom Management
• Chapter 15: Triple-Negative Breast Cancer (TNBC) Management
  • Specific Challenges and Treatment Strategies for TNBC
  • Current and Emerging Therapies for TNBC
• Chapter 16: Male Breast Cancer
  • Epidemiology and Unique Characteristics
  • Therapeutic Approaches
• Chapter 17: Special Considerations in Breast Cancer Therapy
  • Breast Cancer in Pregnancy
  • Breast Cancer in Older Patients
  • Impact of Comorbidities on Treatment
  • Fertility Preservation
  • Survivorship and Long-Term Follow-up

Part IV: Supportive Care and Future Directions

• Chapter 18: Supportive Care During Breast Cancer Treatment
  • Management of Nausea, Vomiting, Fatigue, Pain
  • Cardiotoxicity Management
  • Neuropathy
  • Psychosocial Support
• Chapter 19: Clinical Trials and Drug Development
  • Phases of Clinical Trials
  • Ethical Considerations
  • Emerging Therapies and Research Directions
• Chapter 20: Future Perspectives in Breast Cancer Therapy
  • Precision Medicine and Biomarker-Driven Therapies
  • Liquid Biopsies and MRD Detection
  • Novel Drug Targets and Treatment Modalities

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