Metal Based Neurodegeneration From Molecular Mechanisms to Therapeutic Strategies 2nd Edition by Robert Crichton, Roberta Ward ISBN 1119977142 9781119977148

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Product details:

ISBN 10: 1119977142

ISBN 13: 9781119977148 

Author: Robert Crichton, Roberta Ward 

Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.

Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings,  including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. 

Topics covered include:

• Brain function, physiology and the blood-brain barrier
• Immune system and neuroinflammation
• Aging and mild cognitive impairment, MCI
• Parkinson’s Disease
• Alzheimer’s Disease
• Creutzfelt-Jakob and related prion diseases
• Alcoholic Brain Damage
• Therapeutic strategies to combat the onset and progression of neurological diseases

This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.

Table of contents:

Chapter 1: Brain Function, Physiology and the Blood–Brain Barrier
Chapter 2: Role of Metal Ions in Brain Function, Metal Transport, Storage and Homoeostasis
Chapter 3: Immune System and Neuroinflammation
Chapter 4: Oxidative Stress in Neurodegenerative Diseases
Chapter 5: Ageing and Mild Cognitive Impairment (MCI)
Chapter 6: Parkinson’s Disease
Chapter 7: Alzheimer’s Disease
Chapter 8: Huntington’s Disease and Polyglutamine Expansion Neurodegenerative Diseases
Chapter 9: Friedreich’s Ataxia and Diseases Associated with Expansion of Non-Coding Triplets
Chapter 10: Creutzfeldt–Jakob and Other Prion Diseases
Chapter 11: Amyotrophic Lateral Sclerosis
Chapter 12: Alcoholic Brain Damage
Chapter 13: Other Neurological Diseases
Chapter 14: Therapeutic Strategies to Combat the Onset and Progression of Neurological Diseases
Chapter 15: Concluding Remarks

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Tags: Robert Crichton, Roberta Ward, Metal Based Neurodegeneration, Molecular Mechanisms, Therapeutic Strategies