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Molecular Immunotoxicology 1st Edition by Emanuela Corsini, Henk Van Loveren 9783527335190 3527335196

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Molecular Immunotoxicology 1st Edition Emanuela Corsini Digital Instant Download

Author(s): Emanuela Corsini, Henk Van Loveren
ISBN(s): 9783527335190, 3527335196
Edition: 1
File Details: PDF, 4.95 MB
Year: 2014
Language: english
SKU: EB-4948148 Category: Tags: ,

Molecular Immunotoxicology 1st Edition by Emanuela Corsini, Henk Van Loveren – Ebook PDF Instant Download/Delivery: 9783527335190, 3527335196

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Product details:

ISBN 10: 3527335196

ISBN 13: 9783527335190

Author: Emanuela Corsini, Henk Van Loveren

The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered.
Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models.
Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.

Table of contents:

Chapter 1: The Evolution of Immunotoxicology

Chapter 2: Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity

Chapter 3: Use of Toxicogenomics in Immunotoxicology

Chapter 4: Breakdown of the Molecular Processes Driving the Adverse Outcome Pathways (AOPs) of Skin and Respiratory Sensitization Induction in Humans Exposed to Xenobiotics and Proteins

Chapter 5: Chemical Allergen-Induced Skin Cell Activation

Chapter 6: The Aryl Hydrocarbon Receptor (AhR) as a Mediator of Adverse Immune Reactions

Chapter 7: Immunotoxicological Effects of Pharmaceuticals on Signal Transduction in Innate and Adaptive Immunity

Chapter 8: Promises and Challenges with Immunomodulatory Biologics

Chapter 9: The Nonclinical Evaluation of Biotechnology-Derived Pharmaceuticals, Moving on after the TeGenero Case

Chapter 10: Glucocorticoid-Induced Immunomodulation

Chapter 11: Particulate Matter-Induced Immune Activation

Chapter 12: Genotoxic Mechanisms of PAH-Induced Immunotoxicity

Chapter 13: Immunotoxic Effects of Perfluoroalkylated Compounds: Mechanisms of Action

Chapter 14: Pesticide-Induced Immunotoxicity: Molecular Targets

Chapter 15: Mode of Action of Organotins in Immune Cells

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Tags: Emanuela Corsini, Henk Van Loveren, Molecular, Immunotoxicology