Molecular Nutrition and Diabetes A Volume in the Molecular Nutrition Series 1st Edition by Didac Mauricio ISBN ‎ 0128015853 978-0128015858

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ISBN 10: 0128015853

ISBN 13:  978-0128015858

Author: Didac Mauricio

Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control.

Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes.

• Offers updated information and a perspective on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of diabetes mellitus
• Explores how nutritional factors are involved in the pathogenesis of both type1 and type2 diabetes and their complications
• Investigates the molecular and genetic bases of diabetes and diabetic metabolism through the lens of a rapidly evolving field of molecular nutrition

Table of contents:

 Section 1: General and Introductory Aspects
Nutrition and Diabetes: General Aspects
Dietary Patterns and Insulin Resistance
β-Cell Metabolism, Insulin Production and Secretion: Metabolic Failure Resulting in Diabetes
Diet–Gene Interactions in the Development of Diabetes
Pathogenesis of Type 1 Diabetes: Role of Dietary Factors
Section 2: Molecular Biology of the Cell
Oxidative Stress in Diabetes: Molecular Basis for Diet Supplementation
Impact of Type 2 Diabetes on Skeletal Muscle Mass and Quality
Mechanisms Whereby Whole Grain Cereals Modulate the Prevention of Type 2 Diabetes
Peroxisome Proliferator-Activated Receptors (PPARs) in Glucose Control
High-Fat Diets and β-Cell Dysfunction: Molecular Aspects
Native Fruits, Anthocyanins in Nutraceuticals, and the Insulin Receptor/Insulin Receptor Substrate-1/Akt/Forkhead Box Protein Pathway
Influence of Dietary Factors on Gut Microbiota: The Role on Insulin Resistance and Diabetes Mellitus
Molecular Aspects of Glucose Regulation of Pancreatic β Cells
Metals in Diabetes: Zinc Homeostasis in the Metabolic Syndrome and Diabetes
Cocoa Flavonoids and Insulin Signaling
Dietary Proanthocyanidin Modulation of Pancreatic β Cells: Molecular Aspects
Dietary Whey Protein and Type 2 Diabetes: Molecular Aspects
Dietary Fatty Acids and C-Reactive Protein
Alcoholic Beverage and Insulin Resistance–Mediated Degenerative Diseases of Liver and Brain: Cellular and Molecular Effects
Section 3: Genetic Machinery and its Function
Genetic Variants and Risk of Diabetes
MicroRNA and Diabetes Mellitus
Diabetes Mellitus and Intestinal Niemann-Pick C1–Like 1 Gene Expression
Dietary Long Chain Omega-3 Polyunsaturated Fatty Acids and Inflammatory Gene Expression in Type 2 Diabetes
Polymorphism, Carbohydrates, Fat, and Type 2 Diabetes
Genetic Basis Linking Variants for Diabetes and Obesity with Breast Cancer
Vitamin D Status, Genetics, and Diabetes Risk
NRF2-Mediated Gene Regulation and Glucose Homeostasis
Hepatic Mitochondrial Fatty Acid Oxidation and Type 2 Diabetes
Current Knowledge on the Role of Wnt Signaling Pathway in Glucose Homeostasis
Index

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