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Multi Step Enzyme Catalysis Biotransformations and Chemoenzymatic Synthesis 1st Edition by Eduardo Garcia Junceda ISBN 3527319212 9783527319213

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Multi Step Enzyme Catalysis Biotransformations and Chemoenzymatic Synthesis 1 edition Edition Eduardo Garcia-Junceda (Editor) Digital Instant Download

Author(s): Eduardo Garcia-Junceda (Editor)
ISBN(s): 9783527319213, 3527319212
Edition: 1 edition
File Details: PDF, 2.75 MB
Year: 2008
Language: english
SKU: EB-1551802 Category: Tag:

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ISBN 10: 3527319212 
ISBN 13: 9783527319213
Author: Eduardo Garcia Junceda

The first comprehensive coverage of this unique and interdisciplinary field provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques opens the door to reactions hitherto unknown, making this monograph of great interest to biochemists, organic chemists, and chemists working with/on organometallics, as well as catalytic chemists, biotechnologists, and those working in the pharmaceutical and fine chemical industries.

Multi Step Enzyme Catalysis Biotransformations and Chemoenzymatic Synthesis 1st Table of contents:

  • 1. Asymmetric Transformations by Coupled Enzyme and Metal Catalysis: Dynamic Kinetic Resolution

    • 1.1 Introduction
    • 1.2 Some Fundamentals for DKR
    • 1.3 Enzymes for Kinetic Resolution
    • 1.4 Metal Catalysts for Racemization
    • 1.5 Enzyme-Metal Combination for DKR
    • 1.6 Conclusions
    • References

  • 2. Chemoenzymatic Routes to Enantiomerically Pure Amino Acids and Amines

    • 2.1 Introduction
    • 2.2 Amino Acids
    • 2.3 Amines
    • References

  • 3. Oxidizing Enzymes in Multi-Step Biotransformation Processes

    • 3.1 Oxidizing Enzymes in Biocatalysis
    • 3.2 Classes of Oxidizing Enzymes
    • 3.3 Mechanisms of Biological Oxidation and Implications for Multi-Enzyme Biocatalysis
    • 3.4 Multi-Step Biotransformation Processes Involving Oxidation
    • 3.5 Design and Development of New Multi-Enzyme Oxidizing Processes
    • 3.6 Examples of Multi-Enzyme Biotransformation Processes Involving Oxidation
    • References

  • 4. Aldolases Catalyzed C–C Bond Formation in the Core of Multi-Step Processes

    • 4.1 Introduction
    • 4.2 DHAP-Dependent Aldolases
    • 4.3 Fructose-6-Phosphate Aldolase: An Alternative to DHAP-Dependent Aldolases?
    • 4.4 Combined Use of Aldolases and Isomerases for the Synthesis of Natural and Unnatural Sugars
    • 4.5 Conclusions
    • References

  • 5. Multi-Enzyme Systems for the Synthesis of Glycoconjugates

    • 5.1 Introduction
    • 5.2 In Vitro and In Vivo Multi-Enzyme Systems
    • 5.3 Combinatorial Biocatalysis
    • 5.4 Synthesis and In Situ Regeneration of Nucleotide Sugars
    • 5.5 Synthesis of Oligosaccharides, Glycopeptides and Glycolipids
    • 5.6 Combinatorial Biosynthesis
    • 5.7 Synthesis of Oligosaccharides with Metabolically Engineered Cells
    • 5.8 Conclusions
    • References

  • 6. Enzyme-Catalyzed Cascade Reactions

    • 6.1 Introduction
    • 6.2 Enzyme Immobilization
    • 6.3 Reaction Types: General Considerations
    • 6.4 Chiral Alcohols
    • 6.5 Chiral Amines
    • 6.6 Chiral Carboxylic Acid Derivatives
    • 6.7 C–C Bond Formation: Aldolases
    • 6.8 Oxidations with O2 and H2O2
    • 6.9 Conclusions and Prospects
    • References

  • 7. Multi-modular Synthases as Tools of the Synthetic Chemist

    • 7.1 Introduction
    • 7.2 Excised Domains for Chemical Transformations
    • 7.3 Conclusions
    • References

  • 8. Modifying the Glycosylation Pattern in Actinomycetes by Combinatorial Biosynthesis

    • 8.1 Bioactive Natural Products in Actinomycetes
    • 8.2 Deoxy Sugar Biosynthesis and Gene Clusters
    • 8.3 Characterization of Sugar Biosynthesis Enzymes
    • 8.4 Strategies for the Generation of Novel Glycosylated Derivatives
    • 8.5 Generation of Glycosylated Derivatives of Bioactive Compounds
    • References

  • 9. Microbial Production of DNA Building Blocks

    • 9.1 Introduction
    • 9.2 Screening of Acetaldehyde-Tolerant Deoxyriboaldolase and Its Application for DR5P Synthesis
    • 9.3 Construction of Deoxyriboaldolase-Overexpressing E. coli as a Whole-Cell Catalyst
    • 9.4 Biochemical Retrosynthesis of 2′-Deoxyribonucleosides from Glucose, Acetaldehyde and a Nucleobase: Three-Step Multi-Enzyme-Catalyzed Synthesis

    • 9.5 One-Pot Multi-Step Enzymatic Synthesis of 2′-Deoxyribonucleoside from Glucose, Acetaldehyde and a Nucleobase
    • 9.6 Improvement of the One-Pot Multi-Step Enzymatic Process for Practical Production of 2′-Deoxyribonucleoside from Glucose, Acetaldehyde and a Nucleobase

    • 9.7 Conclusions
    • References

  • 10. Combination of Biocatalysis and Chemical Catalysis for the Preparation of Pharmaceuticals Through Multi-Step Syntheses

     

    • 10.1 Introduction: Biocatalysis and Chemical Catalysis
    • 10.2 Pharmaceuticals with Hydrolases
    • 10.3 Pharmaceuticals with Oxidoreductases
    • 10.4 Pharmaceuticals with Lyases
    • 10.5 Conclusions
    • References

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Tags: Eduardo Garcia Junceda, Enzyme, Biotransformations