Myeloma Therapy Pursuing the Plasma Cell 1st Edition by Sagar Lonial 1597455644 9781597455640
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ISBN 10: 1597455644
ISBN 13: 9781597455640
Author: Sagar Lonial
Therapeutic options for patients with myeloma have dramatically changed over the past 10 years. Beginning with the advances in therapy resulting from the use of high-dose therapy and autologous bone marrow or stem cell tra- plant, we have more than doubled the median survival for patients as a whole, and have now have a wealth of different biology -based treatment approaches for our patients in all disease stages. This book represents state-of-the-art information from many of the leaders in the plasma cell disorders world. Sections focusing on disease pathogenesis and biology, chemotherapy-based approaches, immune -based therapies, currently approved novel agents, developing targets, supportive care, and other plasma cell disorders provides a comprehensive collection and an excellent resource in this time of rapid change in clinical and preclinical disease knowledge. It is important to realize that these changes did not occur in a vacuum. Partnerships between academic institutions, the pharmaceutical industry, patient advocacy groups, the National Cancer Institute, community onco- gists, and ultimately our patients worked closely together to realize these advances, and to effect the radical changes in therapy we have witnessed over the past few years. This book would not have been possible without contri- tions from each of the gifted scientists and clinicians who worked tirelessly to prepare their individual chapters all the while maintaining commitment to the scientific and clinical mission of advancing care.
Myeloma Therapy Pursuing the Plasma Cell 1st Table of contents:
1. Biologic Consideration and Myeloma
1. Staging in Multiple Myeloma
2. Epidemiology of Multiple Myeloma
3. Basic Biology of Plasma Cell Dyscrasias: Focus on the Role of the Tumor Microenviroment
4. Biology-Based Classification and Staging of Multiple Myeloma
5. Cytogenetic Abnormalities in Multiple Myeloma: The Importance of FISH and Cytogenetics
2. Historical and Cytotoxic Agent-Based Therapies for Myeloma
6. Role of Autologous Stem Cell Transplantation in Multiple Myeloma
7. Maintenance Therapy in Multiple Myeloma
8. Therapy for Patients not Eligible for Autologous Transplant
9. Current Role of Anthracyclines in the Treatment of Multiple Myeloma
3. Immune-Based Therapies
10. Allogeneic Transplantation for Multiple Myeloma
11. Immunobiology and Immunotherapy of Multiple Myeloma
12. Antibody and Other Immune-Based Therapies for Myeloma
4. Existing Novel Agents
13. Thalidomide in Patients with Relapsed Multiple Myeloma
14. Thalidomide: Induction Therapy
15. The Role of Bortezomib in the Treatment of Relapsed and Refractory Multiple Myeloma
16. Bortezomib as Induction Therapy in Patients with Multiple Myeloma
17. Lenalidomide in Relapsed or Refractory Multiple Myeloma
18. Lenalidomide for Initial Therapy of Newly Diagnosed Multiple Myeloma
5. Current and Future Targets
19. The Role of Heat Shock Protein 90 as a Therapeutic Target for Multiple Myeloma
20. The PI3 Kinase/Akt Pathway as a Therapeutic Target in Multiple Myeloma
21. The Mammalian Target of Rapamycin and Multiple Myeloma
22. CDK Inhibitors in Multiple Myeloma
23. Fibroblast Growth Factor Receptor 3 and Multiple Myeloma
24. Histone Deacetylase Inhibitors in Multiple Myeloma
25. Death Receptors in Multiple Myeloma and Therapeutic Opportunities
26. Proteasome Inhibitors as Therapy in Multiple Myeloma
6. Supportive Care
27. Pathophysiology of Bone Disease in Multiple Myeloma
28. Anemia and Erythropoeitic Growth Factors in Multiple Myeloma
29. Percutaneous Vertebroplasty and Balloon Kyphoplasty for the Treatment of Acute Painful Pathologic and Nonpathologic Fractures
30. The Role of Anatomic and Functional Imaging in Myeloma
31. Management of Multiple Myeloma Patients with Renal Dysfunction
7. Other Plasma Cell Disorders
32. Waldenstrom’s Macroglobulinemia
33. AL (Immunoglobulin Light-Chain) Amyloidosis
34. POEMS Syndrome and Other Atypical Plasma Cell Disorders
35. Monoclonal Gammopathy of Undetermined Significance
Backmatter
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