Nitric Oxide Biology and Pathobiology 2nd Edition by Louis Ignarro 0123738660 9780123738660

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Product details:

ISBN 10: 0123738660 

ISBN 13: 9780123738660

Author: Louis J. Ignarro

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide’s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.

• Edited by Nobel Laureate Louis J. Ignarro
• Up-to-date therapeutic implications of nitric oxide research
• Authored by world experts on nitric oxide
• Detailed research of the biochemistry and synthesis of nitric oxide

Table of contents:

Section I. Chemical Biology

1.Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes

2.Nitric Oxide Redox Biochemistry in Lipid Environments

3.Mechanisms and Biological Consequences of Peroxynitrite-Dependent Protein Oxidation and Nitration

4.Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes

Section II. Principles of Biology
5. Uncoupling of Endothelial Nitric Oxide Synthase in Cardiovascular Disease and its Pharmacological Modulation
6. Tetrahydrobiopterin: An Essential Cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases
7. Regulation of the Expression of Inducible Nitric Oxide Synthase
8. Molecular Regulation of Inducible Nitric Oxide Synthase
9. Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation
10. Untargeted Discovery of Nitric Oxide-Modified Proteins
11. Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitrated Fatty Acids
12. Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1
13. The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide
14. Nitric Oxide – Asymmetric Dimethylarginine System in Endothelial Cell Senescence
15. The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies
16. Nitric Oxide Formation from Inorganic Nitrate and Nitrite
17. Mechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System
18. Nitrite Therapy for Ischemic Syndromes
19. Nitrite and Heme Globins: Reaction Mechanisms and Physiological Targets

Section III. Principles of Pathobiology
20. Nitric Oxide in Vascular Damage and Regeneration
21. Free Radicals as Atherosclerotic Risk in Relation to Nitric Oxide
22. The Role of Oxidative Stress in Endothelial Dysfunction and Vascular Inflammation
23. Nitric Oxide, Oxidative Stress, Immune Response and Critical Care
24. Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury
25. Nitric Oxide in Airway Inflammation
26. Novel Therapeutic Applications of Nitric Oxide in the Inhibition of Tumor Malignancy and Progression

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Tags: Louis Ignarro, Nitric, Biology, Pathobiology