Nonsense Mediated mRNA Decay 1st Edition by Lynne Maquat 1587062968 9781587062964

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ISBN 10: 1587062968

ISBN 13: 9781587062964

Author: Lynne E. Maquat

Nonsense-Mediated mRNA Decay is the first book devoted to nonsense-mediated mRNA decay (NMD). The rationale for such a book is the enormous information that studies of NMD have provided on the intricacies of post-transcriptional gene expression. The first five sections of the book are divided according to organism and begin with chapters on S. cere

Nonsense Mediated mRNA Decay 1st Table of contents:

Section I: Saccharomyces cerevisiae

1. Features of Nonsense-Mediated mRNA Decay in Saccharomyces cerevisiae

2. All Termination Events Are Not Equal: Premature Termination in Yeast Is Aberrant and Triggers NMD

3. Endogenous Substrates of the Yeast NMD Pathway

Section II: Mammals
4. NMD in Mammalian Cells: A History
5. Human Upf Proteins in NMD
6. NMD and the Immune System
7. Role of SMG-1-Mediated Phosphorylation of Upfl in NMD
8. Physiologic Substrates and Functions for Mammalian NMD
9. NMD and Human Disease
10. Therapies of Nonsense-Associated Diseases

Section III: Caenorhabditis elegans
11. NMD in Caenorhabditis elegans

Section IV: Drosophila melanogaster
12. NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway

Section V: Plants
13. NMD in Plants

Section VI: Evolutionary Aspects of NMD
14. Regulation of Gene Expression by Coupling of Alternative Splicing and NMD
15. NMD and the Evolution of Eukaryotic Gene Structure

Section VII: Roles for NMD Factors Other Than in NMD
16. The SMG-1 Kinase: At the Crossroads of mRNA Surveillance and Stress Response Pathways
17. Staufen 1-Mediated mRNA Decay: A Upfl-Dependent Pathway
18. Upfl Regulates Mammalian Histone mRNA Decay
19. S. cerevisiae Est1 / H. sapiens SMG6 Protein Family Members Function in Telomere Metabolism
20. Nonsense-Associated Altered Splicing

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