Nucleic Acids in Innate Immunity 1st Edition by Ken Ishii, Shizuo Akira 9781420068269 1420068261

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Product details:

ISBN 10: 1420068261

ISBN 13: 9781420068269

Author: Ken J. Ishii, Shizuo Akira

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.

Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.

The second section focuses on the therapeutic applications of immunomodulatory DNA by manipulating released pathogenic nucleic acids as immune system stimulants. The book introduces novel therapeutics developed to prevent or treat infectious diseases, allergic disorders, and cancer, as well as clearing unnecessary or abnormal host molecules.

The final section addresses how the immune system discriminates self and non-self RNA. Recent findings that host (self) nucleic acids are not inert in the immune system beg the question of exactly what elements within DNA or RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation.

Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

Table of contents:

Part I: Roles of Nucleic Acids in Immunity
Chapter 1: Structural Analysis of Toll-Like Receptors
Chapter 2: Antiviral Signaling Through TLRs and RLHs
Chapter 3: Recognition of Virus Invasion by Toll-Like Receptors and RIG-I-Like Helicases
Chapter 4: Characteristics of Dendritic Cell Responses to Nucleic Acids
Chapter 5: Dendritic Cells as Sensors for Foreign and Self Nucleic Acids

Part II: Mechanisms and Therapeutic Applications of Immunomodulatory DNA
Chapter 6: Natural DNA Recognition by Toll-Like Receptor 9 Does Not Rely upon CpG Motifs
Chapter 7: Discrimination of Self and Non-Self DNAs
Chapter 8: Therapeutic Potential of Immunosuppressive Oligonucleotides Expressing TTAGGG Motifs
Chapter 9: Structure/Function of IFNα-Inducing CpG ODNs
Chapter 10: Clinical Development of Oligodeoxynucleotide TLR9 Agonists
Chapter 11: Prospects for TLR9-Based Immunotherapy for Asthma and Allergy
Chapter 12: Toll-Like Receptors in Development of Systemic Autoimmune Disease
Chapter 13: Impacts of Nucleoside Modification on RNA-Mediated Activation of Toll-Like Receptors
Chapter 14: Recognition of Single-Stranded RNA by TLR7 and TLR8
Chapter 15: RNA Interference in Scope of Immune System
Chapter 16: Recognition of RNA and Synthetic Compounds by TLR7 and TLR8
Chapter 17: Helicases at Frontline of RNA Virus Recognition

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Tags: Ken Ishii, Shizuo Akira, Nucleic, Immunity