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Opiate Receptors and Antagonists From Bench to Clinic 1st Edition by Lindsay Burns 1597451975 9781597451970

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Opiate Receptors and Antagonists From Bench to Clinic 1st Edition Lindsay H. Burns Digital Instant Download

Author(s): Lindsay H. Burns, Todd W. Vanderah, Hoau-Yan Wang (auth.), Reginald L. Dean III, Edward J. Bilsky, S. Stevens Negus (eds.)
ISBN(s): 9781597451970, 1597451975
Edition: 1
File Details: PDF, 6.77 MB
Year: 2009
Language: english
SKU: EB-4395900 Category: Tags: , , , , ,

Opiate Receptors and Antagonists From Bench to Clinic 1st Edition by Lindsay H. Burns – Ebook PDF Instant Download/Delivery: 1597451975, 9781597451970

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ISBN 10: 1597451975
ISBN 13: 9781597451970
Author: Lindsay H. Burns

Experts address the role of neuromodulators and opiate receptors in alcohol and drug dependence. They present innovative research techniques, new discoveries, and possible clinical correlates that allow for a much greater understanding of the clinical phenomena surrounding alcohol and narcotic use. Included in this thought-provoking volume are a comprehensive review of the current knowledge of the endogenous opiates, their interactions with the opiate receptors, and the potential relationship that these substances might have in promoting the development of dependence, tolerance, and withdrawal; the translation of the basic physiologic findings occuring during withdrawal to treatment of withdrawal symptoms in the clinical setting; and a physiological explanation for the rationale of using clonidine and naltrexone to accelaerate the detoxification process without undue discomfort.

Opiate Receptors and Antagonists From Bench to Clinic 1st Table of contents:

  1. Opiate Receptors,Neurotransmitters, & Drug Dependence: Basic Science-Clinical Correlates
  2. Editorial The Importance of Science in Clinical Practice
  3. References
  4. Current Clinical Concepts of Dependence Tolerance and Withdrawal
  5. Drug Use, Misuse, and Abuse of Psychoactive Agents
  6. Psychoactive Drugs
  7. Clinical Toxicity
  8. Drug Sources
  9. Tolerance
  10. Opiates
  11. Alcohol, Hypnotics, and Sedatives
  12. Cross-Tolerance
  13. Physical Dependence
  14. Opiates
  15. Alcohol, Hypnotics, and Sedatives
  16. Stimulants
  17. Compulsive Relapsing Drug Use
  18. References
  19. Opiate Receptors and Endorphins: Possible Relevance to Narcotic Addiction
  20. Introduction
  21. The Discovery of Opiate Receptors
  22. Properties and Distribution of Opiate Receptors
  23. Multiple Opiate Receptors
  24. Conformational Changes in Opiate Receptors
  25. Isolation of Opiate Receptors
  26. Discovery of Endogenous Opioid Peptides
  27. Pain and Its Modulation
  28. Narcotic Addiction
  29. Comments and Conclusions
  30. References
  31. Endorphins, Locus Coeruleus, Clonidine, and Lofexidine: a Mechanism for Opiate Withdrawal and New Nonopiate Treatments
  32. Endorphin—LC Connection
  33. Locus Coeruleus Activation Studies
  34. The Opiate Withdrawal Hypothesis
  35. Additional Support for the Hypothesis
  36. Further Implications and Tests of the Hypothesis
  37. Clinical Use and Limitations of Nonopiate Treatments
  38. Demonstration of Endorphin Deficiency or Impairment in Man
  39. References
  40. Alcohol and the Opiate Receptor: Interactions with the Endogenous Opiates
  41. Introduction
  42. Endorphins and Opiate Receptors
  43. Modification of Opiate Withdrawal by Alcohol
  44. Modification of Alcohol Withdrawal by Opiates
  45. Interactions of Opiates, Opiate Antagonists and Alcohol: Effects on Alcohol Preference
  46. Toxic Effects of Interactions Between Alcohol and Opiate Agonists and Antagonists
  47. Ethanol-Opiate Interaction on the Neuroendocrine System
  48. Hypothalamic-Pituitary-A drenal Axis
  49. Hypothalamic-Pituitary-Gonadal Axis
  50. Prolactin
  51. Growth Hormone
  52. Hypothalamic-Pituitary-Thyroid Function
  53. Role of Opiates on Neuroendocrine Function
  54. Clinical Implications of Alcohol-Opiate Interactions
  55. References
  56. Neuro-Endocrine Effects of Opioids
  57. Introduction
  58. Pituitary Polypeptides
  59. Acth
  60. Animal Studies
  61. Opioid-Tolerant Subjects
  62. Gonadotropins
  63. Opiate-Tolerant Subjects
  64. Growth Hormone
  65. Animal Studies
  66. Prolactin (PRL)
  67. Thyroid Stimulating Hormone (TSH)
  68. Hypothalamic Hormones – Vasopressin (AVP)
  69. Oxytocin
  70. Releasing Hormones
  71. Target Organ
  72. Adrenal
  73. Adrenal Medullary Secretion
  74. Testes
  75. Testosterone
  76. Androgenicity
  77. Semen Analyses
  78. Ovary
  79. Thyroid
  80. Miscellaneous
  81. References
  82. Opioids and Psychological Disorders
  83. Introduction
  84. Opiates, Pain, and Analgesia
  85. Opiate Receptors and Endorphins in the Brain
  86. History of Opiate Use
  87. Opioid Interaction with Addiction and Mental Illness
  88. The Effects of Methadone on Suicidal Tendency
  89. Similarities and Differences Between Opioid Agonists and Antipsychotic Agents
  90. The Therapeutic Possibilities for Opioids and Their Antagonists in Mental Disease
  91. The Use of Narcotic Antagonists to Counteract Endorphin Excess
  92. The Use of Opioid Agonists for the Supplementation of Endorphin Deficiency
  93. Effects of Chronic Opiate Use: Safety and Toxicity
  94. Theoretical Models of the Endorphin System
  95. Psychological Homeostasis
  96. The Possible Link Between Opiate and Alcohol Dependence
  97. Satisfaction, Reward, and Euphoria May Be Mediated Through the Opiate Receptors

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