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Optimal Treatment Strategies For End Stage Renal Failure 1st Edition by Claude Jacobs ISBN 1423700945 9781423700944

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Author(s): Claude Jacobs
ISBN(s): 9781423700944, 1423700945
Edition: 1
File Details: PDF, 1.14 MB
Year: 2002
Language: english
SKU: EB-1889356 Category: Tag:

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ISBN 10: 1423700945 
ISBN 13: 9781423700944
Author: Claude Jacobs

During the past 40 years there have been major conceptual and technical advances in the domain of dialysis methods and renal/organ transplantation for long-term treatment of patients with End-Stage Renal Failure (ESRF). This now enables better defined, more selective strategies of treatment to be undertaken, according to patient-specific criteria such as age or underlying renal disease also taking into account the lifetime duration of these treatments. For many patients this implies necessary successive changes of mode of therapy depending on their availability, occurrence of medical/technical complications or failure and social environment and economic factors. This rationale has inspired the structure of this volume which is divided into four sections: 1/A descriptive overview of the various modes of renal replacement therapy (RRT): Extracorporeal dialysis/filtration, peritoneal dialysis, kidney and multi-organ transplantation. 2/Most appropriate indications and use of these methods, respective advantages, drawbacks and outcome in children, pregnant women and elderly patients. 3/ In diabetic patients and in patients with heredity/congenital diseases.4/ The ethical issues generated by this new domain in Medicine by limitations in treatment facilities or medical dilemas for acceptance, best technical choices, withdrawal or termination of RRT in individual patients. Finally, contributors from Eastern European Coutnries, Africa and Far Eastern Countries analyse the current status of RRT in their respective geographical area and the ways and means required for a wider implementation of RRT in thus far lesser economically developed countries where the great majority of the populations still have no access to these life-saving therapeutic procedures.

Optimal Treatment Strategies For End Stage Renal Failure 1st Table of contents:

Part I: Understanding End-Stage Renal Failure (ESRF)

Chapter 1: The Epidemiology and Pathophysiology of ESRF

  • 1.1 Defining End-Stage Renal Failure
  • 1.2 Global and Regional Epidemiology of ESRF
  • 1.3 Major Causes of ESRF: Diabetes, Hypertension, Glomerulonephritis, Polycystic Kidney Disease, etc.
  • 1.4 Progression of Chronic Kidney Disease (CKD) to ESRF
  • 1.5 Uremic Syndrome: Clinical Manifestations and Pathophysiology

Chapter 2: Pre-ESRF Management and Patient Preparation

  • 2.1 Delayed Progression of CKD: Renoprotective Strategies
  • 2.2 Conservative Management for Patients Not Opting for Renal Replacement Therapy
  • 2.3 Preparation for Dialysis: Vascular Access Creation (Fistula, Graft)
  • 2.4 Preparation for Peritoneal Dialysis: Catheter Insertion and Training
  • 2.5 Pre-emptive Transplant Evaluation and Listing

Part II: Dialysis Modalities

Chapter 3: Hemodialysis: Principles and Practice

  • 3.1 Principles of Hemodialysis: Dialyzers, Dialysate, Machines
  • 3.2 Vascular Access for Hemodialysis: AV Fistulae, Grafts, Catheters
  • 3.3 Hemodialysis Prescriptions: Adequacy (Kt/V), Frequency, Duration
  • 3.4 In-Center vs. Home Hemodialysis: Patient Selection and Outcomes
  • 3.5 Common Complications During Hemodialysis: Hypotension, Cramps, Arrhythmias

Chapter 4: Peritoneal Dialysis: Principles and Practice

  • 4.1 Principles of Peritoneal Dialysis: Peritoneum as a Membrane
  • 4.2 Peritoneal Access: Catheter Insertion and Care
  • 4.3 Types of Peritoneal Dialysis: CAPD (Continuous Ambulatory), APD (Automated)
  • 4.4 Peritoneal Dialysis Prescriptions: Adequacy and Fluid Management
  • 4.5 Complications of Peritoneal Dialysis: Peritonitis, Encapsulating Peritoneal Sclerosis

Chapter 5: Comparing Dialysis Modalities: Patient Selection and Outcomes

  • 5.1 Decision-Making Framework: Hemodialysis vs. Peritoneal Dialysis
  • 5.2 Patient-Specific Factors Influencing Modality Choice
  • 5.3 Quality of Life and Psychosocial Aspects of Dialysis
  • 5.4 Survival and Clinical Outcomes Data for HD vs. PD
  • 5.5 Shared Decision-Making in Modality Selection

Part III: Kidney Transplantation

Chapter 6: Renal Transplantation: Evaluation and Surgical Aspects

  • 6.1 Overview of Kidney Transplantation: Types (Deceased Donor, Living Donor)
  • 6.2 Recipient Evaluation and Listing Criteria
  • 6.3 Donor Evaluation: Living Related, Living Unrelated, Deceased Donors
  • 6.4 Surgical Techniques for Kidney Transplantation
  • 6.5 Immunological Considerations: HLA Matching, Cross-matching, Sensitization

Chapter 7: Immunosuppression and Post-Transplant Management

  • 7.1 Principles of Immunosuppression: Induction, Maintenance, Anti-Rejection Therapy
  • 7.2 Major Immunosuppressive Agents: Calcineurin Inhibitors, Antiproliferatives, Steroids
  • 7.3 Monitoring and Adjusting Immunosuppression
  • 7.4 Early Post-Transplant Complications: Surgical, Infection, Rejection
  • 7.5 Long-Term Post-Transplant Management: Monitoring Graft Function, Cardiovascular Risk

Chapter 8: Complications and Outcomes of Renal Transplantation

  • 8.1 Acute and Chronic Rejection: Diagnosis and Management
  • 8.2 Infections in Transplant Recipients: Opportunistic Pathogens, CMV, BK Virus
  • 8.3 Post-Transplant Malignancies: PTLD, Skin Cancers
  • 8.4 Cardiovascular Disease in Transplant Recipients
  • 8.5 Long-Term Graft and Patient Survival Rates
  • 8.6 Quality of Life After Transplantation

Part IV: Supportive Care and Special Considerations

Chapter 9: Management of ESRF Complications

  • 9.1 Anemia in CKD and ESRF: Iron, ESAs, Transfusions
  • 9.2 Mineral and Bone Disorder (MBD) in CKD: Hyperphosphatemia, Hyperparathyroidism
  • 9.3 Cardiovascular Disease: Hypertension, Heart Failure, Atherosclerosis
  • 9.4 Neurological Complications: Uremic Neuropathy, Dialysis Dementia
  • 9.5 Dermatological, Gastrointestinal, and Endocrine Complications

Chapter 10: Nutritional Management in ESRF

  • 10.1 Dietary Guidelines for Pre-Dialysis CKD
  • 10.2 Nutritional Needs for Hemodialysis Patients
  • 10.3 Nutritional Needs for Peritoneal Dialysis Patients
  • 10.4 Nutritional Considerations for Transplant Recipients
  • 10.5 Malnutrition and Cachexia in ESRF

Chapter 11: ESRF in Special Populations

  • 11.1 Diabetes and ESRF: Specific Management Challenges
  • 11.2 ESRF in the Elderly: Frailty, Comorbidity, Decision-Making
  • 11.3 Pediatric ESRF: Growth, Development, Modality Selection
  • 11.4 ESRF in Patients with Specific Comorbidities (e.g., Liver Disease, Cancer)

Part V: Ethical, Economic, and Future Perspectives

Chapter 12: Ethical Considerations and End-of-Life Care in ESRF

  • 12.1 Patient Autonomy and Informed Consent
  • 12.2 Withdrawal of Dialysis: Ethical Frameworks and Practical Guidelines
  • 12.3 Palliative Care and Symptom Management in ESRF
  • 12.4 Ethical Issues in Organ Donation and Allocation
  • 12.5 Communication with Patients and Families

Chapter 13: Economic and Societal Aspects of ESRF Care

  • 13.1 Cost of ESRF Treatment: Dialysis vs. Transplantation
  • 13.2 Healthcare Policies and Reimbursement Models for Renal Care
  • 13.3 Global Disparities in Access to ESRF Treatment
  • 13.4 Quality Assurance and Performance Measures in Renal Programs

Chapter 14: Emerging Therapies and Future Directions

  • 14.1 Advances in Dialysis Technology: Wearable/Implantable Devices
  • 14.2 Novel Immunosuppressive Strategies and Tolerance Induction
  • 14.3 Regenerative Medicine and Bioartificial Kidneys
  • 14.4 Personalized Medicine in Nephrology
  • 14.5 Prevention of CKD Progression: New Pharmacological Targets

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