Oxidative Folding of Peptides and Proteins 1st Edition by Luis Moroder, Johannes Buchner 9780854041480 0854041486
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Product details:
ISBN 10: 0854041486
ISBN 13: 9780854041480
Author: Luis Moroder, Johannes Buchner
The formation of disulfide bonds is probably the most influential modification of peptides and proteins. An elaborate set of cellular machinery exists to catalyze and guide this process. In recent years, significant developments have been made in both our understanding of the in vivo situation and the in vitro manipulation of disulfide bonds. This is the first monograph to provide a comprehensive overview of this exciting and rapidly developing area. It offers in-depth insights into the mechanisms of in vivo and in vitro oxidative folding of proteins as well as mono- and multiple-stranded peptides. Procedures applied for laboratory and industrial purposes are also discussed by top experts in the field. The book describes the enzymes involved in the correct oxidative folding of cysteine-containing proteins in prokaryotes and eukaryotes. It then goes on to discuss the mimicking of these enzymes for successful in vitro folding of proteins (including synthetic replicates) and to deal with important issues concerning cysteine-rich peptides. The ability of natural bioactive peptides to fold correctly, and in high yields, to form defined structural motifs using cysteine sequence patterns is still puzzling. With this in mind, synthetic procedures for establishing native cysteine frameworks are discussed using selected examples, such as the potential of selenocysteines. The biotechnological and pharmaceutical relevance of proteins, peptides, their variants and synthetic replicates is continuously increasing. Consequently, this book is invaluable for peptide and protein chemists involved in related research and production.
Table of contents:
Chapter 1: Oxidative Folding of Proteins in vivo
Chapter 2: Oxidative Folding of Proteins in vitro
Chapter 3: Redox Potentials of Cysteine Residues in Peptides and Proteins: Methods for their Determination
Chapter 4: Engineered Disulfide Bonds for Protein Design
Chapter 5: Selenocysteine as a Probe of Oxidative Protein Folding
Chapter 6: Oxidative Folding of Peptides in vitro
Chapter 7: Cystine-based Scaffolds for Functional Miniature Proteins
Chapter 8: Selenocystine Peptides – Synthesis, Folding and Applications
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Tags: Luis Moroder, Johannes Buchner, Oxidative, Proteins