Pain Free Biochemistry An Essential Guide for the Health Sciences 1st Edition by Paul Engel 9780470060469 0470060468

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Product details:

ISBN 10: 0470060468

ISBN 13: 9780470060469

Author: Paul C. Engel

Having taught biochemistry to all sorts of students, from nurses to chemical engineers, for more than 30 years, Professor Paul Engel knows how to take the ‘pain’ out of your studies. For those who are a bit wobbly on molecules, bonds, ions, etc. ‘Pain-Free Biochemistry’ also has just enough supporting chemistry slipped in where appropriate to help things make sense. Accessible, enjoyable to read and packed with a wealth of clinical examples from heart disease to cancer and blood clotting to antibiotics, this handy textbook will reveal how biochemistry is fundamental to clinical practice and everyday life. Drugs, diet, disease, DNA – it all comes down to biochemistry.

Table of contents:

SECTION 1: Foundations

• TOPIC 1: Why biochemistry?

• TOPIC 2: Remarkableness of life

• CHEMISTRY I: The basic structure of substances

• CHEMISTRY II: Atomic structure, valency and bonding

• CHEMISTRY III: Protons, acids, bases, concentration and the pH scale

• TOPIC 3: Shape, molecular recognition and proteins

• TOPIC 4: Proteins: molecular necklaces

• TOPIC 5: Chemical transformations in the living organism: metabolism

• TOPIC 6: Reactions, catalysts and enzymes

• TOPIC 7: Specificity, saturation and active sites

• TOPIC 8: Structure of metabolism: anabolism and catabolism

• CHEMISTRY IV: Equilibrium

• TOPIC 9: Catabolism: degradation vs energy metabolism

• CHEMISTRY V: Oxidation and reduction

• TOPIC 10: Oxidation and reduction in metabolism

SECTION 2: Catabolism

• CHEMISTRY VI: Aldehydes, ketones and sugars

• TOPIC 11: Carbohydrates in metabolism

• TOPIC 12: Glucose inside the body

• TOPIC 13: Breakdown of sugar: glycolysis

• TOPIC 14: Aerobic oxidation of pyruvate: Krebs cycle

• TOPIC 15: Respiratory chain and oxidative phosphorylation

• TOPIC 16: Mobilising carbohydrate stores: glycogenolysis

• CHEMISTRY VII: Alcohols, esters, glycerol, fatty acids and triglycerides

• CHEMISTRY VIII: Hydrophobic, hydrophilic and amphiphilic

• TOPIC 17: Phospholipids and membranes

• CHEMISTRY IX: Saturated and unsaturated

• TOPIC 18: Fats as an energy source

• TOPIC 19: Fats: digestion, transport, storage and mobilisation

• TOPIC 20: Fats: oxidation of fatty acids

• TOPIC 21: Ketone bodies in health and disease

• TOPIC 22: Dietary fat: essential fatty acids

• TOPIC 23: Protein and amino acid breakdown

• TOPIC 24: Shedding excess amino groups: urea cycle

SECTION 3: Anabolism and Control

• TOPIC 25: Is anabolism just catabolism backwards?

• TOPIC 26: Making new glucose: gluconeogenesis

• TOPIC 27: Fatty acid biosynthesis

• TOPIC 28: NADPH and the pentose phosphate pathway

• CHEMISTRY X: Isotopes

• TOPIC 29: Red cells and white cells: reactive oxygen

• TOPIC 30: The need for metabolic control

• TOPIC 31: Relationship of fats and carbohydrates

SECTION 4: Genes and Protein Synthesis

• TOPIC 32: The idea of genes

• TOPIC 33: DNA and the double helix

• TOPIC 34: The genetic code and mRNA

• TOPIC 35: Protein synthesis, ribosomes and tRNA

• TOPIC 36: Genetic differences and disease

• TOPIC 37: Genetic variability: drug metabolism

• TOPIC 38: Mutagens, radiation and ageing

• TOPIC 39: Gene expression control

• TOPIC 40: Targeting DNA and protein synthesis

SECTION 5: Physiological Systems and Clinical Issues

• TOPIC 41: Hormones and second messengers

• TOPIC 42: Switching enzymes on and off

• TOPIC 43: Insulin, glucagon and adrenaline

• TOPIC 44: Diabetes

• TOPIC 45: Steroid hormones and receptors

• TOPIC 46: Pituitary hormones and feedback

• TOPIC 47: Thyroid hormones

• TOPIC 48: Adrenal cortex

• TOPIC 49: Prostaglandins and inflammation

• TOPIC 50: Membrane transport

• TOPIC 51: Nerve and muscle

• TOPIC 52: pH homeostasis

• TOPIC 53: Diagnostic markers

• TOPIC 54: Blood, bleeding and clotting

SECTION 6: Appendices

• APPENDIX 1: pH and neutrality

• APPENDIX 2: Crystallography

• APPENDIX 3: Protein structure and folding

• APPENDIX 4: Equilibrium constant

• APPENDIX 5: Phosphate chemistry

• APPENDIX 6: Coenzymes and cofactors

• APPENDIX 7: Coenzyme A

• APPENDIX 8: Krebs cycle evidence

• APPENDIX 9: β-oxidation evidence

• APPENDIX 10: Isoenzymes

• APPENDIX 11: Genetic code

• APPENDIX 12: Mutations

• APPENDIX 13: Restriction enzymes

• APPENDIX 14: Enzyme inhibition

• APPENDIX 15: Electrophoresis

• APPENDIX 16: Chromatography and mass spectrometry

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