Particle Toxicology 1st Edition by Ken Donaldson, Paul Borm – Ebook PDF Instant Download/Delivery: 1420003143, 9781420003147
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Product details:
ISBN 10: 1420003143
ISBN 13: 9781420003147
Author: Ken Donaldson, Paul Borm
Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to transl
Table of contents:
1 An Introduction to Particle Toxicology: From Coal Mining to Nanotechnology
2 Mineralogy and Structure of Pathogenic Particles
3 Particle Dosimetry: Deposition and Clearance from the Respiratory Tract and Translocation Towards Extra-Pulmonary Sites
4 Particulate Air Pollutants and Small Airway Remodeling
5 Particle-Mediated Extracellular Oxidative Stress in the Lung
6 Particles and Cellular Oxidative and Nitrosative Stress
7 Interaction of Particles with Membranes
8 Particle-Associated Metals and Oxidative Stress in Signaling
9 Proinflammatory Effects of Particles on Macrophages and Epithelial Cells
10 Cell-Signaling Pathways Elicited by Particulates
11 Particle-Associated Organics and Proinflammatory Signaling
12 The Asbestos Model of Interstitial Pulmonary Fibrosis: TNF-a and TGF-ß1 as Mediators of Asbestos-Induced Lung Fibrogenesis
13 Effect of Particles on the Immune System
14 Effects of Particles on the Cardiovascular System
15 Susceptibility to Particle Effects
16 Genotoxic Effects of Particles
17 Approaches to the Toxicological Testing of Particles
18 Models for Testing the Pulmonary Toxicity of Particles: Lung Bioassay Screening Studies in Male Rats with a New Formulation of TiO2 Particulates
19 Air Pollution and Human Brain Pathology: A Role for Air Pollutants in the Pathogenesis of Alzheimer’s Disease
20 Biologically Based Lung Dosimetry and Exposure-Dose- Response Models for Poorly Soluble Inhaled Particles*
21 Nanoparticles in Medicine
22 The Toxicology of Inhaled Particles: Summing Up an Emerging Conceptual Framework
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Tags: Ken Donaldson, Paul Borm, Particle, Toxicology