Pathway Analysis for Drug Discovery Computational Infrastructure and Applications 1st Edition by Anton Yuryev, Sean Ekins 0470399260 9780470399262

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Product details:

ISBN 10: 0470399260 

ISBN 13: 9780470399262

Author: Anton Yuryev, Sean Ekins

This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

Table of contents:

1. Introduction to Pathway Analysis
Anton Yuryev

2. Software Infrastructure and Data Model for Pathway Analysis
Fedor Bokov and Anton Yuryev

3. Automatic Pathway Inference in Heterogeneous Biological Association Networks
Anton Yuryev, Andrey Kalinin, and Nikolai Daraselia

4. Algorithmic Basis for Pathway Visualization
Sergey Simakov, Iaroslav Ispolatov, Sergei Maslov, and Alexander Nikitin

5. Pathway Analysis of High-Throughput Experimental Data
Andrey Y. Sivachenko

6. Integrative Pathway Analysis of Disease Molecular Data
Andrej Bugrim, Zoltan Dezso, Yuri Nikolsky, and Tatiana Nikolskaya

7. Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise
John Farley, Laurent L. Ozbun, and Michael J. Birrer

8. Mammalian Proteome and Toxicant Network Analysis
Sean Ekins and Craig N. Giroux

9. Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an Illustrative Example
Mark P. Kühnel, Bojana Cosovic, Goran Medic, Robert B. Russell, and Gordana Apic

10. Impact of Chemistry Information on Pathway Analysis
Sreenivas Devidas

11. Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks
Sergei Maslov and Iaroslav Ispolatov

12. An Adaptive System Model of the Yeast Glucose Sensor System
Todor Vujasinovic and André Siniša Žampera

13. Present and Future of Pathway Analysis in Drug Discovery
Anton Yuryev

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Tags: Anton Yuryev, Sean Ekins, Pathway, Discovery