Pharmacogenomics in Drug Discovery and Development 2nd Edition by Qing Yan 1493947583 9781493947584

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ISBN 10: 1493947583

ISBN 13: 9781493947584

Author: Qing Yan

Covering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development, Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the “root” of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, Pharmacogenomics in Drug Discovery and Development, Second Edition seeks to serve both professionals and novices with comprehensive resources and a holistic view for the translation of pharmacogenomics into better preventive and personalized medical care.

Pharmacogenomics in Drug Discovery and Development 2nd Table of contents:

Chapter 1: The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery – Qing Yan
Chapter 2: Applications of Microarrays and Biochips in Pharmacogenomics – Gary Hardiman
Chapter 3: Confounding in Genetic Association Studies and Its Solutions – Donglei Hu, Elad Ziv
Chapter 4: Pharmacogenetics of Membrane Transporters: A Review of Current Approaches – Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg
Chapter 5: Pharmacogenomics of Drug-Metabolizing Enzymes and Drug Transporters in Chemotherapy – Tessa M. Bosch
Chapter 6: Pharmacogenomics of G Protein-Coupled Receptor Signaling: Insights from Health and Disease – Miles D. Thompson, David E. C. Cole, Pedro A. Jose
Chapter 7: G Protein-Coupled Receptors Disrupted in Human Genetic Disease – Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, David E. C. Cole
Chapter 8: G Protein-Coupled Receptor Pharmacogenetics – Miles D. Thompson, Katherine A. Siminoivitch, David E. C. Cole
Chapter 9: Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders – Hamid Mostafavi, Abdolmaleky, Cassandra L. Smith, Jin-Rong Zhou, Sam Thiagalingam
Chapter 10: Pharmacogenomics in Alzheimer’s Disease – Ramon Cacabelos
Chapter 11: Pharmacogenetics of Asthma – Gregory A. Hawkins, Stephen P. Peters
Chapter 12: From SNPs to Functional Studies in Cardiovascular Pharmacogenomics – Sharon Cresci
Chapter 13: Pharmacogenomics in Gastrointestinal Disorders – Michael Camilleri, Yuri A. Saito
Chapter 14: Pharmacogenomics in Rheumatoid Arthritis – Prabha Ranganathan
Chapter 15: Cancer Pharmacogenetics – Sharon Marsh
Chapter 16: Pharmacogenomics in the Preclinical Development of Vaccines: Evaluation of Efficacy and Systemic Toxicity in the Mouse Using Array Technology – Karin J. Regnstrom
Chapter 17: Pharmacogenomics in the Evaluation of Efficacy and Adverse Events During Clinical Development of Vaccines – Lennart J. Nilsson, Karin J. Regnstrom

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