Pharmacogenomics 2nd Edition by Werner Kalow, Urs Meyer, Rachel Tyndale 9781574448788 1574448781

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Product details:

ISBN 10: 1574448781

ISBN 13: 9781574448788

Author: Werner Kalow, Urs B. Meyer, Rachel F. Tyndale

Reflecting the shift from genetics to genomics in the pharmaceutical sphere, this Second Edition traces the evolution of the science of pharmacogenetics and gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.

Table of contents:

1. Introduction

2. Historical Aspects of Pharmacogenetics

3. Pharmacogenomics and the Promise of Personalized Medicine

4. Current Status of Pharmacogenomics

5. Drug Metabolism

6. Receptors

7. Pharmacogenetics and Drug Transporters

8. Variability of Induction Processes

9. Pharmacogenetics and Cardiac Ion Channels

10. Interethnic Differences in Drug Response

11. Clinical Viewpoints

12. Regulatory Perceptions

13. Methodologies in Genetics and Genomics

14. Tools of the Trade: The Technologies and Challenges of Pharmacogenomics

15. Technologies for the Analysis of Single Nucleotide Polymorphisms

16. Molecular Diagnostics and Development of Biotechnology-based Diagnostics

17. Metabonomics

18. MALDI-TOF MS: Application in Genomics

19. Measuring Gene Expression: Transcriptional Insights into Functional Biology

20. From Genotype to Phenotype

21. Proteomics

22. Haplotype Structure

23. Pharmacoepigenetics: From Basic Epigenetics to Therapeutic Applications

24. Bioinformatics: Aims and Methodologies of a New Discipline

25. Internet Resources

26. Applied Bioinformatics

27. Genetics of Common Diseases

28. Mapping of Disease Loci

29. Positional Cloning and Disease Gene Identification

30. Genome Variation Influencing Gene Copy Number and Disease

31. Conclusions

32. General Conclusions and Future Directions

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Tags: Werner Kalow, Urs Meyer, Rachel Tyndale, Pharmacogenomics