Polymorphism in the pharmaceutical industry 1st Edition by Rolf Hilfiker 9783527311460 3527311467

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ISBN 10: 3527311467
ISBN 13: 9783527311460 
Author:  Rolf Hilfiker

Edited by one of the leading experts in the field, this handbook emphasizes why solid-state issues are important, which approaches should be taken to avoid problems and exploit the opportunities offered by solid state properties in the pharmaceutical and agricultural industries.
With its practical approach, this is at once a guideline for development chemists just entering the field as well as a high-quality source of reference material for specialists in the pharmaceutical and chemical industry, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent departments

Polymorphism in the pharmaceutical industry 1st Table of contents:

Chapter 1
Relevance of Solid-state Properties for Pharmaceutical Products (Pages: 1-19)
Rolf Hilfiker, Fritz Blatter, Markus von Raumer

Chapter 2
Thermodynamics of Polymorphs (Pages: 21-42)
Sachin Lohani, David J. W. Grant

Chapter 3
Characterization of Polymorphic Systems Using Thermal Analysis (Pages: 43-79)
Duncan Q. M. Craig

Chapter 4
Solid-state NMR Spectroscopy (Pages: 81-93)
Joseph W. Lubach, Eric J. Munson

Chapter 5
Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization (Pages: 95-138)
John M. Chalmers, Geoffrey Dent

Chapter 6
Crystallography for Polymorphs (Pages: 139-166)
Philippe Ochsenbein, Kurt J. Schenk

Chapter 7
Light Microscopy (Pages: 167-209)
Gary Nichols

Chapter 8
The Importance of Solvates (Pages: 211-233)
Ulrich J. Griesser

Chapter 9
Physical Characterization of Hygroscopicity in Pharmaceutical Solids (Pages: 235-258)
Susan M. Reutzel-Edens, Ann W. Newman

Chapter 10
The Amorphous State (Pages: 259-285)
Samuel Petit, Gérard Coquerel

Chapter 11
Approaches to Polymorphism Screening (Pages: 287-308)
Rolf Hilfiker, Susan M. De Paul, Martin Szelagiewicz

Chapter 12
Salt Selection (Pages: 309-332)
Peter Heinrich Stahl, Bertrand Sutter

Chapter 13
Processing-induced Phase Transformations and Their Implications on Pharmaceutical Product Quality (Pages: 333-364)
Ramprakash Govindarajan, Raj Suryanarayanan

Chapter 14
Polymorphism and Patents from a Chemist’s Point of View (Pages: 365-384)
Joel Bernstein

Chapter 15
Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications (Pages: 385-403)

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