Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 9th Edition by John Bilezikian 9781119266563 1119266564

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Product details:

ISBN 10: 1119266564

ISBN 13: 9781119266563

Author: John P. Bilezikian

Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism.

The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. This vital resource: 

• Provides the most accurate, up-to-date evidence-based information on basic and clinical bone science
• Includes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers
• Captures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics
• Presents a new companion website with useful supplementary materials at www.asbmrprimer.com

Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

Table of contents:

Section I: Molecular and Cellular Determinants of Bone Structure and Function

1. Early Skeletal Morphogenesis in Embryonic Development

2. Endochondral Ossification

3. Local and Circulating Osteoprogenitor Cells and Lineages

4. Osteoblasts: Function, Development, and Regulation

5. Osteocytes

6. Osteoclast Biology and Bone Resorption

7. Signal Transduction Cascades Controlling Osteoblast Differentiation

8. The TGF‐β Superfamily in Bone Formation and Maintenance

9. Recent Developments in Understanding the Role of Wnt Signaling in Skeletal Development and Disease

10. Mechanotransduction in Bone Formation and Maintenance

11. The Composition of Bone

12. Assessment of Bone Mass, Structure, and Quality in Rodents

13. Skeletal Healing

14. Biomechanics of Fracture Healing

Section II: Skeletal Physiology
15. Human Fetal and Neonatal Bone Development
16. Skeletal Growth: a Major Determinant of Bone’s Structural Diversity in Women and Men
17. Racial Differences in the Acquisition and Age‐related Loss of Bone Strength
18. Calcium, Vitamin D, and Other Nutrients During Growth
19. Mechanical Loading and the Developing Skeleton
20. Pregnancy and Lactation
21. Menopause and Age‐related Bone Loss

Section III: Mineral Homeostasis
22. Regulation of Calcium Homeostasis
23. Magnesium Homeostasis
24. Fetal Calcium Metabolism
25. FGF23 and the Regulation of Phosphorus Metabolism
26. Gonadal Steroids
27. Parathyroid Hormone
28. Parathyroid Hormone‐Related Protein
29. Calcium‐Sensing Receptor
30. Vitamin D: Production, Metabolism, Action, and Clinical Requirements

Section IV: Investigation of Metabolic Bone Diseases
31. Techniques of Bone Mass Measurement in Children with Risk Factors for Osteoporosis
32. Standard Techniques of Bone Mass Measurement in Adults
33. Advanced Techniques of Bone Mass Measurements and Strength in Adults
34. Magnetic Resonance Imaging of Bone
35. Trabecular Bone Score
36. Reference Point Indentation
37. Biochemical Markers of Bone Turnover in Osteoporosis
38. Scintigraphy and PET in Metabolic Bone Disease
39. Bone Histomorphometry in Clinical Practice
40. Diagnosis and Classification of Vertebral Fracture
41. FRAX

Section V: Genetics of Bone
42. Introduction to Genetics
43. Animal Models: Genetic Manipulation
44. Animal Models: Allelic Determinants for Bone Mineral Density
45. Transcriptional Profiling for Genetic Assessment
46. Approaches to Genetic Testing
47. Human Genome‐Wide Association Studies
48. Translational Genetics of Osteoporosis

Section VI: Osteoporosis
49. Osteoporosis
50. The Epidemiology of Osteoporotic Fractures
51. Fracture Liaison Service
52. Sex Steroids and the Pathogenesis of Osteoporosis
53. Juvenile Osteoporosis
54. Transplantation Osteoporosis
55. Premenopausal Osteoporosis
56. Osteoporosis in Men
57. Bone Stress Injuries
58. Inflammation‐Induced Bone Loss in the Rheumatic Diseases
59. Glucocorticoid‐Induced Osteoporosis
60. Human Immunodeficiency Virus and Bone
61. Effects on the Skeleton from Medications Used to Treat Nonskeletal Disorders
62. Diabetes and Fracture Risk
63. Obesity and Skeletal Health
64. Sarcopenia and Osteoporosis
65. Management of Osteoporosis in Patients with Chronic Kidney Disease
66. Other Secondary Causes of Osteoporosis
67. Exercise for Osteoporotic Fracture Prevention and Management
68. Prevention of Falls
69. Nutritional Support for Osteoporosis
70. Estrogens, Selective Estrogen Receptor Modulators, and Tissue‐Selective Estrogen Complex
71. Bisphosphonates for Postmenopausal Osteoporosis
72. Denosumab
73. Parathyroid Hormone and Abaloparatide Treatment for Osteoporosis
74. Combination Anabolic and Antiresorptive Therapy for Osteoporosis
75. Strontium Ranelate and Calcitonin
76. Adverse Effects of Drugs for Osteoporosis
77. Orthopedic Principles of Fracture Management
78. Adherence to Osteoporosis Therapies
79. Cost‐Effectiveness of Osteoporosis Treatment
80. Future Therapies

Section VII: Metabolic Bone Diseases
81. Approach to Parathyroid Disorders
82. Primary Hyperparathyroidism
83. Familial States of Primary Hyperparathyroidism
84. Non‐Parathyroid Hypercalcemia
85. Hypocalcemia
86. Hypoparathyroidism
87. Pseudohypoparathyroidism
88. Disorders of Phosphate Homeostasis
89. Rickets and Osteomalacia
90. Pathophysiology and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder
91. Disorders of Mineral Metabolism in Childhood
92. Paget Disease of Bone
93. Epidemiology, Diagnosis, Evaluation, and Treatment of Nephrolithiasis
94. Immobilization and Burns

Section VIII: Cancer and Bone
95. Mechanisms of Osteolytic and Osteoblastic Skeletal Lesions
96. Clinical and Preclinical Imaging in Osseous Metastatic Disease
97. Metastatic Tumors and Bone
98. Myeloma Bone Disease and Other Hematological Malignancies
99. Osteogenic Osteosarcoma
100. Skeletal Complications of Breast and Prostate Cancer Therapies
101. Bone Cancer and Pain
102. Radiotherapy‐Induced Osteoporosis
103. Skeletal Complications of Childhood Cancer
104. Medical Prevention and Treatment of Bone Metastases
105. Radiotherapy of Skeletal Metastases
106. Concepts and Surgical Treatment of Metastatic Bone Disease

Section IX: Sclerosing and Dysplastic Bone Diseases
107. Sclerosing Bone Disorders
108. Fibrous Dysplasia
109. The Osteochondrodysplasias
110. Ischemic and Infiltrative Disorders of Bone
111. Tumoral Calcinosis – Dermatomyositis
112. Genetic Disorders of Heterotopic Ossification: Fibrodysplasia Ossificans Progressiva and Progressive Osseous Heteroplasia
113. Osteogenesis Imperfecta
114. Fibrillinopathies: Skeletal Manifestations of Marfan Syndrome and Marfan‐Related Conditions
115. Hypophosphatasia and Other Enzyme Deficiencies Affecting the Skeleton

Section X: Oral and Maxillofacial Biology and Pathology
116. Craniofacial Morphogenesis
117. Development and Structure of Teeth and Periodontal Teeth
118. Genetic Craniofacial Disorders Affecting the Dentition
119. Pathology of the Hard Tissues of the Jaws

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