Principles and Practice of Movement Disorders 2nd Edition by Stanley Fahn, Joseph Jankovic, Mark Hallett ISBN 1437723691 9781437723694

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ISBN 10: 1437723691 

ISBN 13: 9781437723694

Author: Stanley Fahn, Joseph Jankovic, Mark Hallett

Table of contents: 

Section I: Overview
Chapter 1: Clinical overview and phenomenology of movement disorders
Fundamentals
Differential diagnosis of hypokinesias
Evaluation of a dyskinesia
Differential diagnosis of dyskinesias
The clinical approach to differentiate the dyskinesias
Conclusions
Chapter 2: Motor control
Segmental inputs onto the alpha motoneuron
Supraspinal control of the alpha motoneuron
The basal ganglia
Parkinson disease
Dystonia
Dyskinesias
Cerebellum
Ataxia
Cortical control mechanisms
Apraxia
What is a voluntary movement?
Disorders of willed movement
Acknowledgment
Chapter 3: Functional neuroanatomy of the basal ganglia
Introduction
Neurotransmitters
Components of the basal ganglia
Circuitry of the basal ganglia
Physiology
Section II: Hypokinetic disorders
Chapter 4: Parkinsonism
Introduction
Clinical features
Bradykinesia
Tremor
Rigidity and flexed posture
Loss of postural reflexes
Freezing
Other motor abnormalities
Nonmotor manifestations
Autonomic dysfunction
Cognitive and neurobehavioral abnormalities
Sleep disorders
Sensory abnormalities
Clinical-pathologic correlations
Subtypes and natural history of Parkinson disease
Differential diagnosis
Clinical rating scales and other assessments
Epidemiology
Laboratory tests
Presymptomatic diagnosis and biomarkers
Pathologic findings
Chapter 5: Current concepts on the etiology and pathogenesis of Parkinson disease
Anatomical and biochemical pathology of PD
Interconnected pathogenic mechanisms of PD
Genetics as an etiologic factor of PD
Environmental factors contributing to etiology of or protection against PD
Endogenous factors that contribute to the etiology of PD
Where does PD pathology begin? How does it progress? Braak’s staging system
Clues on pathogenesis from monogenic PD
Lewy bodies in fetal dopaminergic neurons; infectious protein hypothesis
Multiple hit hypothesis with a central role of α-synuclein
Animal models
Chapter 6: Medical treatment of Parkinson disease
Introduction
Therapeutic principles
Therapeutic choices available for Parkinson disease
Medications available for Parkinson disease
Treatment of early-stage Parkinson disease
Treatment of mild-stage Parkinson disease
Treatment of moderate-stage Parkinson disease
Treatment of advanced-stage Parkinson disease
Chapter 7: Surgical treatment of Parkinson disease and other movement disorders
Introduction
Functional anatomy of the basal ganglia
Techniques of stereotactic surgery
Thalamotomy
Ablative lesions of the pallidum and subthalamic nucleus
Deep brain stimulation
Deep brain stimulation for hyperkinetic and other disorders
Vagus nerve and other stimulation procedures
Brain grafting
Chapter 8: Nonmotor problems in Parkinson disease
Introduction
Sensory symptoms
Autonomic dysfunctions: bladder and sexual problems
Other autonomic symptoms
Respiratory distress
Difficulties at night and daytime sleepiness
Fatigue
Depression, anxiety, and change in personality
Cognitive problems
Dementia and confusion
Compulsive behaviors
Psychosis: hallucinations and paranoia
Quality of life
Chapter 9: Atypical parkinsonism, parkinsonism-plus syndromes, and secondary parkinsonian disorders
Introduction
Progressive supranuclear palsy
Multiple system atrophy
Corticobasal degeneration
Parkinsonism–dementia syndromes
Frontotemporal dementias and other tauopathies
Parkinsonism–dementia–amyotrophic lateral sclerosis complex of Guam
Heredodegenerative parkinsonism
Secondary parkinsonism
Appendix
Chapter 10: Gait disorders
Balance
Gait
Gait disorders
Therapeutic considerations
Chapter 11: Stiffness syndromes
Spasticity
Stiff-person (stiff-man) syndrome
Syndromes of continuous muscle activity
Section III: Hyperkinetic disorders
Chapter 12: Dystonia
Historical highlights
Impact and overview of genetic discoveries
Phenomenology of dystonic movements
Epidemiology
Classification of torsion dystonia
Pseudodystonia
Oppenheim dystonia (DYT1)
Dopa-responsive dystonia (DRD)
Rapid-onset dystonia–parkinsonism (RDP)
Myoclonus–dystonia
Secondary dystonias
Lubag (X-linked dystonia–parkinsonism, XDP)
Pathophysiology and pathoanatomy of primary dystonia
Biochemistry and neuroimaging
Chapter 13: Treatment of dystonia
Physical and supportive therapy
Dopaminergic therapy
Antidopaminergic therapy
Anticholinergic therapy
Other pharmacologic therapies
Botulinum toxin
Surgical treatment of dystonia
Other therapies
Therapeutic guidelines
Appendix
Chapter 14: Huntington disease
Introduction
Epidemiology
Clinical aspects
Natural course
Neuroimaging
Neuropathology and neurochemistry
Genetics
Pathogenesis
Treatment
Experimental therapeutics
Appendix
Chapter 15: Chorea, ballism, and athetosis
Introduction
Dentatorubral-pallidoluysian atrophy and HD-like disorders
Other Huntington disease-like disorders
Neuroacanthocytosis
Neurodegeneration with brain iron accumulation
Other familial choreas
Infectious chorea
Postinfectious and autoimmune choreas
Other autoimmune choreas
Other choreas
Treatment of chorea
Ballism
Treatment of ballism
Athetosis
Treatment of athetosis
Appendix
Chapter 16: Tics and Tourette syndrome
Introduction
Phenomenology of tics
Clinical features of Tourette syndrome
Pathogenesis
Genetics
Etiology of tics (secondary tourettism)
Epidemiology
Treatment
Appendix
Chapter 17: Stereotypies
Pathophysiology of stereotypies
Physiologic stereotypies
Developmental disorders
Schizophrenia and catatonia
Obsessive-compulsive disorder and tic disorders
Other stereotypies
Treatment
Chapter 18: Tremors
Introduction
Assessment of tremors
Rest tremors
Postural tremors
Kinetic tremors
Pathophysiologic mechanisms of rest and action tremors
Other tremors
Appendix
Chapter 19: The tardive syndromes
Overview
Fundamentals and definitions
Dopamine receptors and their antagonists
“Atypical” antipsychotics
Neurologic side effects of dopamine D2 receptor antagonists
Tardive syndromes
Treatment of tardive syndromes
Chapter 20: Myoclonus
Classification of myoclonus
Neurophysiologic assessment
Making the diagnosis
Focal myoclonus
Axial myoclonus
Multifocal and generalized cortical myoclonus
Drug treatment of generalized or multifocal myoclonus
Chapter 21: Ataxia
Sporadic ataxia
Genetic ataxia
Diagnostic plan
Recovery from cerebellar injury; therapy
Chapter 22: The paroxysmal dyskinesias
Introduction
Definitions: transient, paroxysmal, episodic, and periodic
Historical aspects
Classification of the paroxysmal dyskinesias
Paroxysmal kinesigenic dyskinesia (PKD)
Paroxysmal nonkinesigenic dyskinesia (PNKD)
Paroxysmal exertional dyskinesia (PED)
Episodic ataxias
Molecular genetics of paroxysmal dyskinesias
Miscellany
Summary
Chapter 23: Restless legs and peripheral movement disorders
Restless legs syndrome and periodic movements of sleep
Peripheral movement disorders
Chapter 24: Wilson disease
Wilson disease
Treatment of Wilson disease
Hereditary deficiency of ceruloplasmin
Chapter 25: Psychogenic movement disorders
Introduction
Degree of certainty of the diagnosis of a psychogenic movement disorder
Definitions of psychiatric terminology
Clues suggesting the presence of a psychogenic movement disorder
Diagnostic approach and clinical features
Psychogenic dystonia
Psychogenic nondystonic movement disorders
Approaches to the patient suspected of having a psychogenic movement disorder
Results of treatment
Movement disorders caused by psychiatric conditions but not regarded as psychogenic

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