Principles of Biochemistry 5th Edition by Moran Horton Scrimgeour Perry ISBN 0321707338 9780321707338

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ISBN 10: 0321707338 
ISBN 13: 9780321707338
Author: Moran Horton Scrimgeour Perry

Principles of Biochemistry 5th Table of contents:

PART ONE: Introduction
1 Introduction to Biochemistry
1.1 Biochemistry Is a Modern Science
1.2 The Chemical Elements of Life
1.3 Many Important Macromolecules Are Polymers
1.4 The Energetics of Life
1.5 Biochemistry and Evolution
1.6 The Cell Is the Basic Unit of Life
1.7 Prokaryotic Cells: Structural Features
1.8 Eukaryotic Cells: Structural Features
1.9 A Picture of the Living Cell
1.10 Biochemistry Is Multidisciplinary
Appendix: The Special Terminology of Biochemistry
Selected Readings
2 Water
2.1 The Water Molecule Is Polar
2.2 Hydrogen Bonding in Water
2.3 Water Is an Excellent Solvent
2.4 Nonpolar Substances Are Insoluble in Water
2.5 Noncovalent Interactions
2.6 Water Is Nucleophilic
2.7 Ionization of Water
2.8 The pH Scale
2.9 Acid Dissociation Constants of Weak Acids
2.10 Buffered Solutions Resist Changes in pH
Summary
Problems
Selected Readings
PART TWO: Structure and Function
3 Amino Acids and the Primary Structures of Proteins
3.1 General Structure of Amino Acids
3.2 Structures of the 20 Common Amino Acids
3.3 Other Amino Acids and Amino Acid Derivatives
3.4 Ionization of Amino Acids
3.5 Peptide Bonds Link Amino Acids in Proteins
3.6 Protein Purification Techniques
3.7 Analytical Techniques
3.8 Amino Acid Composition of Proteins
3.9 Determining the Sequence of Amino Acid Residues
3.10 Protein Sequencing Strategies
3.11 Comparisons of the Primary Structures of Proteins Reveal Evolutionary Relationships
Summary
Problems
Selected Readings
4 Proteins: Three-Dimensional Structure and Function
4.1 There Are Four Levels of Protein Structure
4.2 Methods for Determining Protein Structure
4.3 The Conformation of the Peptide Group
4.4 The α Helix
4.5 β Strands and b Sheets
4.6 Loops and Turns
4.7 Tertiary Structure of Proteins
4.8 Quaternary Structure
4.9 Protein–Protein Interactions
4.10 Protein Denaturation and Renaturation
4.11 Protein Folding and Stability
4.12 Collagen, a Fibrous Protein
4.13 Structure of Myoglobin and Hemoglobin
4.14 Oxygen Binding to Myoglobin and Hemoglobin
4.15 Antibodies Bind Specific Antigens
Summary
Problems
Selected Readings
5 Properties of Enzymes
5.1 The Six Classes of Enzymes
5.2 Kinetic Experiments Reveal Enzyme Properties
5.3 The Michaelis-Menten Equation
5.4 Kinetic Constants Indicate Enzyme Activity and Catalytic Proficiency
5.5 Measurement of K[sub(m)] and V[sub(max)]5.6 Kinetics of Multisubstrate Reactions
5.7 Reversible Enzyme Inhibition
5.8 Irreversible Enzyme Inhibition
5.9 Regulation of Enzyme Activity
5.10 Multienzyme Complexes and Multifunctional Enzymes
Summary
Problems
Selected Readings
6 Mechanisms of Enzymes
6.1 The Terminology of Mechanistic Chemistry
6.2 Catalysts Stabilize Transition States
6.3 Chemical Modes of Enzymatic Catalysis
6.4 Diffusion-Controlled Reactions
6.5 Modes of Enzymatic Catalysis
6.6 Serine Proteases
6.7 Lysozyme
6.8 Arginine Kinase
Summary
Problems
Selected Readings
7 Coenzymes and Vitamins
7.1 Many Enzymes Require Inorganic Cations
7.2 Coenzyme Classification
7.3 ATP and Other Nucleotide Cosubstrates
7.4 NAD⊕ and NADP⊕
7.5 FAD and FMN
7.6 Coenzyme A and Acyl Carrier Protein
7.7 Thiamine Diphosphate
7.8 Pyridoxal Phosphate
7.9 Vitamin C
7.10 Biotin
7.11 Tetrahydrofolate
7.12 Cobalamin
7.13 Lipoamide
7.14 Lipid Vitamins
7.15 Ubiquinone
7.16 Protein Coenzymes
7.17 Cytochromes
Summary
Problems
Selected Readings
8 Carbohydrates
8.1 Most Monosaccharides Are Chiral Compounds
8.2 Cyclization of Aldoses and Ketoses
8.3 Conformations of Monosaccharides
8.4 Derivatives of Monosaccharides
8.5 Disaccharides and Other Glycosides
8.6 Polysaccharides
8.7 Glycoconjugates
Summary
Problems
Selected Readings
9 Lipids and Membranes
9.1 Structural and Functional Diversity of Lipids
9.2 Fatty Acids
9.3 Triacylglycerols
9.4 Glycerophospholipids
9.5 Sphingolipids
9.6 Steroids
9.7 Other Biologically Important Lipids
9.8 Biological Membranes
9.9 Membranes Are Dynamic Structures
9.10 Membrane Transport
9.11 Transduction of Extracellular Signals
Summary
Problems
Selected Readings
PART THREE: Metabolism and Bioenergetics
10 Introduction to Metabolism
10.1 Metabolism Is a Network of Reactions
10.2 Metabolic Pathways
10.3 Major Pathways in Cells
10.4 Compartmentation and Interorgan Metabolism
10.5 Actual Gibbs Free Energy Change, Not Standard Free Energy Change, Determines the Direction of M
10.6 The Free Energy of ATP Hydrolysis
10.7 The Metabolic Roles of ATP
10.8 Thioesters Have High Free Energies of Hydrolysis
10.9 Reduced Coenzymes Conserve Energy from Biological Oxidations
10.10 Experimental Methods for Studying Metabolism
Summary
Problems
Selected Readings
11 Glycolysis
11.1 The Enzymatic Reactions of Glycolysis
11.2 The Ten Steps of Glycolysis
11.3 The Fate of Pryuvate
11.4 Free Energy Changes in Glycolysis
11.5 Regulation of Glycolysis
11.6 Other Sugars Can Enter Glycolysis
11.7 The Entner–Doudoroff Pathway in Bacteria
Summary
Problems
Selected Readings
12 Gluconeogenesis, the Pentose Phosphate Pathway, and Glycogen Metabolism
12.1 Gluconeogenesis
12.2 Precursors for Gluconeogenesis
12.3 Regulation of Gluconeogenesis
12.4 The Pentose Phosphate Pathway
12.5 Glycogen Metabolism
12.6 Regulation of Glycogen Metabolism in Mammals
12.7 Maintenance of Glucose Levels in Mammals
12.8 Glycogen Storage Diseases
Summary
Problems
Selected Readings
13 The Citric Acid Cycle
13.1 Conversion of Pyruvate to Acetyl CoA
13.2 The Citric Acid Cycle Oxidizes Acetyl CoA
13.3 The Citric Acid Cycle Enzymes
13.4 Entry of Pyruvate Into Mitochondria
13.5 Reduced Coenzymes Can Fuel the Production of ATP
13.6 Regulation of the Citric Acid Cycle
13.7 The Citric Acid Cycle Isn’t Always a “Cycle”
13.8 The Glyoxylate Pathway
13.9 Evolution of the Citric Acid Cycle
Summary
Problems
Selected Readings
14 Electron Transport and ATP Synthesis
14.1 Overview of Membrane-associated Electron Transport and ATP Synthesis
14.2 The Mitochondrion
14.3 The Chemiosmotic Theory and the Protonmotive Force
14.4 Electron Transport
14.5 Complex I
14.6 Complex II
14.7 Complex III
14.8 Complex IV
14.9 Complex V: ATP Synthase
14.10 Active Transport of ATP, ADP, and Pi Across the Mitochondrial Membrane
14.11 The P/O Ratio
14.12 NADH Shuttle Mechanisms in Eukaryotes
14.13 Other Terminal Electron Acceptors and Donors
14.14 Superoxide Anions
Summary
Problems
Selected Readings
15 Photosynthesis
15.1 Light-Gathering Pigments
15.2 Bacterial Photosystems
15.3 Plant Photosynthesis
15.4 Fixation of CO[sub(2)]: The Calvin Cycle
15.5 Sucrose and Starch Metabolism in Plants
15.6 Additional Carbon Fixation Pathways
Summary
Problems
Selected Readings
16 Lipid Metabolism
16.1 Fatty Acid Synthesis
16.2 Synthesis of Triacylglycerols and Glycerophospholipids
16.3 Synthesis of Eicosanoids
16.4 Synthesis of Ether Lipids
16.5 Synthesis of Sphingolipids
16.6 Synthesis of Cholesterol
16.7 Fatty Acid Oxidation
16.8 Eukaryotic Lipids Are Made at a Variety of Sites
16.9 Lipid Metabolism Is Regulated by Hormones in Mammals
16.10 Absorption and Mobilization of Fuel Lipids in Mammals
16.11 Ketone Bodies Are Fuel Molecules
Summary
Problems
Selected Readings
17 Amino Acid Metabolism
17.1 The Nitrogen Cycle and Nitrogen Fixation
17.2 Assimilation of Ammonia
17.3 Synthesis of Amino Acids
17.4 Amino Acids as Metabolic Precursors
17.5 Protein Turnover
17.6 Amino Acid Catabolism
17.7 The Urea Cycle Converts Ammonia into Urea
17.8 Renal Glutamine Metabolism Produces Bicarbonate
Summary
Problems
Selected Readings
18 Nucleotide Metabolism
18.1 Synthesis of Purine Nucleotides
18.2 Other Purine Nucleotides Are Synthesized from IMP
18.3 Synthesis of Pyrimidine Nucleotides
18.4 CTP Is Synthesized from UMP
18.5 Reduction of Ribonucleotides to Deoxyribonucleotides
18.6 Methylation of dUMP Produces dTMP
18.7 Modified Nucleotides
18.8 Salvage of Purines and Pyrimidines
18.9 Purine Catabolism
18.10 Pyrimidine Catabolism
Summary
Problems
Selected Readings
PART FOUR: Biological Information Flow
19 Nucleic Acids
19.1 Nucleotides Are the Building Blocks of Nucleic Acids
19.2 DNA Is Double-Stranded
19.3 DNA Can Be Supercoiled
19.4 Cells Contain Several Kinds of RNA
19.5 Nucleosomes and Chromatin
19.6 Nucleases and Hydrolysis of Nucleic Acids
19.7 Uses of Restriction Endocucleases
Summary
Problems
Selected Readings
20 DNA Replication, Repair, and Recombination
20.1 Chromosomal DNA Replication Is Bidirectional
20.2 DNA Polymerase
20.3 DNA Polymerase Synthesizes Two Strands Simultaneously
20.4 Model of the Replisome
20.5 Initiation and Termination of DNA Replication
20.6 DNA Replication in Eukaryotes
20.7 DNA Replication in Eukaryotes
20.8 Repair of Damaged DNA
20.9 Homologous Recombination
Summary
Problems
Selected Readings
21 Transcription and RNA Processing
21.1 Types of RNA
21.2 RNA Polymerase
21.3 Transcription Initiation
21.4 Transcription Termination
21.5 Transcription in Eukaryotes
21.6 Transcription of Genes Is Regulated
21.7 The lac Operon, an Example of Negative and Positive Regulation
21.8 Post-transcriptional Modification of RNA
21.9 Eukaryotic mRNA Processing
Summary
Problems
Selected Readings
22 Protein Synthesis
22.1 The Genetic Code
22.2 Transfer RNA
22.3 Aminoacyl-tRNA Synthetases
22.4 Ribosomes
22.5 Initiation of Translation
22.6 Chain Elongation During Protein Synthesis Is a Three-Step Microcycle
22.7 Termination of Translation
22.8 Protein Synthesis Is Energetically Expensive
22.9 Regulation of Protein Synthesis
22.10 Post-translational Processing

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