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Progress in Medicinal Chemistry 1st Edition by F D King, G Lawton ISBN 0444528083 9780444528087

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Progress in Medicinal Chemistry 44 1st Edition F.D. King And G. Lawton (Eds.) Digital Instant Download

Author(s): F.D. King and G. Lawton (Eds.)
ISBN(s): 9780444517371, 0444517375
Edition: 1
File Details: PDF, 3.03 MB
Year: 2006
Language: english
SKU: EB-2012988 Category: Tag:

Progress in Medicinal Chemistry 1st Edition by F D King, G Lawton – Ebook PDF Instant Download/Delivery:0444528083, 9780444528087
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Product details: 

ISBN 10: 0444528083

ISBN 13: 9780444528087

Author: F. D. King, G. Lawton

The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a ‘quality lead’, where these ‘quality leads’ come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.

*Presents the latest research in the field of drug discovery
*Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry
*Available as an online resource via ScienceDirect

Table of contents: 

Chapter 1. Hit and Lead Identification: Efficient Practices for Drug Discovery
Introduction
Hit and Lead Identification Practices
Lead Identification as Reported for Specific Targets
Conclusion
References
Chapter 2. DPPIV Inhibition: Promising Therapy for the Treatment of Type 2 Diabetes
Introduction
Medicinal Chemistry and Preclinical Studies
Clinical Data for Oral DPPIV Inhibitors
Conclusions
Authors Note
References
Chapter 3. Recent Progress Toward Nonpeptide Ligands for the Melanocortin-4 Receptor
Introduction
Cyclohexylpiperidines as Potent MC4R Agonists
Cyclohexylpiperazines and Phenylpiperidines
Phenylpiperazines as MC4R Agonists
Other Classes of MC4R Agonists
Compounds Mimicking α-MSH and its Peptide Analogues
From Agonists to Antagonists
Small Molecule MC4R Antagonists from Initial Screen Hits
Other Nonpeptide MC4R Ligands
Interaction of the MC4R with Ligands
Medicinal Chemistry
Conclusion
References
Chapter 4. Tuberculosis Chemotherapy: Recent Developments and Future Perspectives
Introduction
TB Drug Development Pipeline
Potential New Drug Targets
Concluding Comments
Acknowledgments
References

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F D King,G Lawton,Medicinal