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Protein Lipid Interactions From Membrane Domains to Cellular Networks 1st Edition by Lukas K Tamm ISBN 3527311513 9783527311514

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Protein Lipid Interactions From Membrane Domains to Cellular Networks 1st Edition Lukas K. Tamm (Editor) Digital Instant Download

Author(s): Lukas K. Tamm (Editor)
ISBN(s): 9783527311514, 3527311513
Edition: 1
File Details: PDF, 10.89 MB
Year: 2005
Language: english
SKU: EB-2164452 Category: Tag:

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ISBN 10: 3527311513 
ISBN 13: 9783527311514
Author: Lukas K Tamm

In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.

Protein Lipid Interactions From Membrane Domains to Cellular Networks 1st Table of contents:

Part I: Fundamental Principles of Membranes and Interactions

Chapter 1: The Lipid Bilayer: Structure, Dynamics, and Diversity

  • Dr. Sarah J. Thompson (University of California, Berkeley)
  • 1.1 Lipid Composition and Organization in Biological Membranes
  • 1.2 Lipid Phase Behavior: Liquid-Disordered, Liquid-Ordered, Gel Phases
  • 1.3 Membrane Fluidity and Elasticity
  • 1.4 Lipid Asymmetry and Transbilayer Movement
  • 1.5 Curvature Stress and Membrane Bending

Chapter 2: Overview of Membrane Proteins and Their Integration

  • Dr. Michael R. Evans (University of Oxford)
  • 2.1 Types of Membrane Proteins: Integral, Peripheral, Lipid-Anchored
  • 2.2 Mechanisms of Membrane Protein Insertion and Folding
  • 2.3 Topology and Orientation of Transmembrane Proteins
  • 2.4 Helix-Helix and Beta-Sheet Interactions in Membrane Proteins

Chapter 3: Thermodynamics and Kinetics of Protein-Lipid Binding

  • Dr. Anna K. Schmidt (Max Planck Institute for Biophysical Chemistry)
  • 3.1 Basic Principles of Protein-Lipid Association
  • 3.2 Electrostatic Interactions: Charged Lipids and Protein Surfaces
  • 3.3 Hydrophobic Interactions: Lipid Acyl Chain Binding
  • 3.4 Specific Headgroup Recognition: PI(4,5)P2, PS, Cholestrol
  • 3.5 Kinetic Aspects of Protein Recruitment to Membranes

Part II: Mechanisms and Specificity of Protein-Lipid Interactions

Chapter 4: Protein-Induced Membrane Curvature and Remodeling

  • Dr. David L. Pincus (Weizmann Institute of Science)
  • 4.1 Sensing and Inducing Membrane Curvature
  • 4.2 BAR Domain Proteins and Membrane Scaffolding
  • 4.3 Dynamin and Membrane Fission
  • 4.4 ESCRT Complexes in Membrane Budding and Severance
  • 4.5 F-BAR, I-BAR, and EFC/FCH Domains

Chapter 5: Lipid-Mediated Protein Localization and Signaling

  • Dr. Clara B. Mendez (University of Cambridge)
  • 5.1 Phosphoinositides: Key Regulators of Cellular Processes
  • 5.2 Sphingolipids and Glycolipids in Signaling Pathways
  • 5.3 Role of Cholesterol in Protein Trafficking and Function
  • 5.4 Lipid Binding Domains: PH, PX, FYVE, C1, C2 Domains
  • 5.5 Recruitment and Activation of Signaling Enzymes

Chapter 6: Annular Lipids and Protein Function

  • Dr. John W. Smith (Vanderbilt University)
  • 6.1 Definition and Identification of Annular Lipids
  • 6.2 Influence of Annular Lipids on Ion Channels and Transporters
  • 6.3 Role of Lipids in GPCR Activation and Dynamics
  • 6.4 Allosteric Modulation of Membrane Proteins by Lipids

Part III: Membrane Domains and Higher-Order Organization

Chapter 7: Lipid Rafts: Structure, Dynamics, and Controversy

  • Dr. Isabelle Dubois (University of Geneva)
  • 7.1 Historical Perspective and Evolution of the Lipid Raft Concept
  • 7.2 Biophysical Properties and Composition of Lipid Rafts
  • 7.3 Experimental Methods for Studying Lipid Rafts (Fluorescence Microscopy, Force Microscopy)
  • 7.4 Raft-Associated Proteins and Their Functions
  • 7.5 Caveolae and Flotillin Domains

Chapter 8: Protein-Driven Membrane Organization

  • Dr. Robert A. Chen (Massachusetts Institute of Technology)
  • 8.1 Protein Crowding and Phase Separation
  • 8.2 Cytoskeleton-Membrane Interactions and Anchoring
  • 8.3 Formation of Supramolecular Protein Complexes in Membranes
  • 8.4 Membrane Skeletal Proteins and Their Role in Domain Formation
  • 8.5 Membrane Compartmentalization by Physical Barriers

Chapter 9: Artificial and Reconstituted Membrane Systems

  • Dr. Lena J. Schmidt (Technical University of Munich)
  • 9.1 Liposomes, Nanodiscs, and Supported Lipid Bilayers
  • 9.2 Giant Unilamellar Vesicles (GUVs) for Studying Phase Separation
  • 9.3 Reconstitution of Membrane Proteins for Functional Studies
  • 9.4 Microfluidics and Patterning of Membranes

Part IV: Methodologies for Studying Protein-Lipid Interactions

Chapter 10: Biophysical Techniques for Characterizing Interactions

  • Dr. Klaus M. Richter (University of Vienna)
  • 10.1 Nuclear Magnetic Resonance (NMR) Spectroscopy
  • 10.2 Electron Paramagnetic Resonance (EPR) Spectroscopy
  • 10.3 X-ray Crystallography and Cryo-Electron Microscopy (Cryo-EM)
  • 10.4 Surface Plasmon Resonance (SPR) and Quartz Crystal Microbalance (QCM)
  • 10.5 Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC)

Chapter 11: Advanced Microscopy and Imaging Approaches

  • Dr. Evelyn G. White (University of Southern California)
  • 11.1 Fluorescence Recovery After Photobleaching (FRAP) and Fluorescence Correlation Spectroscopy (FCS)
  • 11.2 Single-Molecule Tracking
  • 11.3 Super-Resolution Microscopy (STORM, PALM, STED)
  • 11.4 Atomic Force Microscopy (AFM) and Membrane Topography

Chapter 12: Computational and Simulation Approaches

  • Dr. Olivier C. Dubois (École Normale Supérieure)
  • 12.1 Molecular Dynamics (MD) Simulations of Protein-Lipid Systems
  • 12.2 Coarse-Grained Simulations for Large-Scale Membrane Phenomena
  • 12.3 Docking and Binding Free Energy Calculations
  • 12.4 Machine Learning in Predicting Protein-Lipid Interactions

Part V: Cellular Networks, Disease, and Future Directions

Chapter 13: Protein-Lipid Interactions in Cellular Signaling Networks

  • Dr. Peter W. Johnson (Rockefeller University)
  • 13.1 Membrane Receptors and Signal Transduction
  • 13.2 Lipid Second Messengers and Their Production
  • 13.3 Crosstalk Between Protein and Lipid Signaling Pathways
  • 13.4 Examples: PI3K/Akt Pathway, GPCR Signaling

Chapter 14: Protein-Lipid Dynamics in Membrane Trafficking and Fusion

  • Dr. Nina S. Olsen (Karolinska Institute)
  • 14.1 Endocytosis and Exocytosis: Mechanisms and Lipid Roles
  • 14.2 Vesicle Budding and Fusion Events
  • 14.3 Lipid Flippases, Floppases, and Scramblases in Trafficking
  • 14.4 SNARE Proteins and Lipid Mixing

Chapter 15: Protein-Lipid Interactions in Disease

  • Dr. Eleanor D. Graham (University of Edinburgh)
  • 15.1 Neurodegenerative Diseases: Alzheimer’s, Parkinson’s, Huntington’s
  • 15.2 Cancer: Aberrant Lipid Metabolism and Signaling
  • 15.3 Metabolic Disorders: Diabetes, Obesity
  • 15.4 Infectious Diseases: Viral Entry and Bacterial Pathogenesis
  • 15.5 Channelopathies and Lipid Dysregulation

Chapter 16: Emerging Concepts and Future Frontiers

  • Lukas K. Tamm (University of Virginia)
  • 16.1 Integrating Multi-Omics Data for Membrane Biology
  • 16.2 Therapeutic Targeting of Protein-Lipid Interfaces
  • 16.3 The Role of Membrane Phase Transitions in Cellular Function
  • 16.4 Next-Generation Technologies for Studying Live Cell Dynamics
  • 16.5 Open Questions and Challenges in the Field

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Tags: Lukas K Tamm, Protein, Lipid, Domains