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Ribozymes and RNA Catalysis RSC Biomolecular Sciences 1st Edition by David Lilley, Fritz Eckstein 9780854042531 0854042539

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Ribozymes and RNA Catalysis RSC Biomolecular Sciences 1st Edition David M.J. Lilley Digital Instant Download

Author(s): David M.J. Lilley, Fritz Eckstein
ISBN(s): 9780854042531, 0854042539
Edition: 1
File Details: PDF, 150.60 MB
Year: 2008
Language: english
SKU: EB-1916628 Category: Tags: ,

Ribozymes and RNA Catalysis RSC Biomolecular Sciences 1st Edition by David Lilley, Fritz Eckstein – Ebook PDF Instant Download/Delivery: 9780854042531, 0854042539

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Product details:

ISBN 10: 0854042539

ISBN 13: 9780854042531

Author: David M.J. Lilley, Fritz Eckstein

The discovery that RNA could act as a macromolecular catalyst in the cell, signified a paradigm shift in molecular biology. Ribozymes and RNA Catalysis takes the reader through the origins of catalysis in RNA and necessarily includes significant discussion of structure and folding. The main focus of the book concerns chemical mechanism with extensive comment on how, despite the importance of RNA catalysis in the cell, its origins are still poorly understood and often controversial. The reader is given an outline of the important role of RNA catalysis in many aspects of cell function, including RNA processing and translation. There has been a significant coming together in the field of RNA in recent years and this book offers a compelling review of the whole field to date. Written by leading experts in their field, who in turn review the structural and mechanistic data for all known ribozymes this book is well suited for undergraduates, postgraduates and researchers in catalytic chemistry as well as those in related fields who require a unique overview of the subject.

Table of contents:

  1. Ribozymes and RNA catalysis: Introduction and primer

  2. Proton transfer in ribozyme catalysis

  3. Finding the Hammerhead ribozyme active site

  4. Hammerhead ribozyme crystal structures and catalysis

  5. The Hairpin and Varkud satellite ribozymes

  6. Catalytic mechanism of the HDV ribozyme

  7. Mammalian self-cleaving ribozymes

  8. The structure and action of glmS ribozymes

  9. A structural analysis of Ribonuclease P

  10. Group I introns: Biochemical and crystallographic characterization of the active site structure

  11. Group II introns: Catalysts for splicing, genomic change and evolution

  12. The GIR1 branching ribozyme

  13. Is the spliceosome a ribozyme?

  14. Peptidyl transferase mechanism: The ribosome as a ribozyme

  15. Folding mechanisms of Group I ribozymes

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Tags: David Lilley, Fritz Eckstein, Ribozymes, Catalysis