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Stem Cell Therapy for Autoimmune Disease 1st Edition by Richard K Burt ISBN 1587060310 9781587060311

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Stem Cell Therapy for Autoimmune Disease 1st Edition Richard K. Burt (Author) Digital Instant Download

Author(s): Richard K. Burt (Author)
ISBN(s): 9781587060311, 1000724670
Edition: 1
File Details: PDF, 110.93 MB
Year: 2004
Language: english
SKU: EB-11911220 Category: Tag:

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Product details: 

ISBN 10: 1587060310

ISBN 13: 9781587060311

Author: Richard K. Burt 

Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Table of contents: 

1. When is a Stem Cell Really a Stem Cell?
2. Embryonic Stem Cells: Unique Potential to Treat Autoimmune Diseases
3. Neural Stem Cells and Oligodendrocyte Progenitors in the Central Nervous System
4. Turning Blood into Liver
5. Adipose Tissue-Derived Adult Stem Cells: Potential for Cell Therapy
6. Hematopoietic Stem Cell Biology: Relevance to Autoimmunity
7. Properties and Therapeutic Potentials of Adult Stem Cells from Bone Marrow Stroma (MSCs)
8. Regeneration of Cardiomyocytes from Bone Marrow Stem Cells and Application to Cell Transplantation Therapy
9. Clinical Trials of Hematopoietic Stem Cells for Cardiac and Peripheral Vascular Diseases
10. The Stem Cell Continuum: A Plastic Plasticity
11. Adult Stem Cell Plasticity
12. Collection and Expansion of Stem Cells
13. The Extracellular Matrix as a Substrate for Stem Cell Growth and Development and Tissue Repair
14. Gene Transfer into Human Hematopoietic Stem Cells: Problems and Perspectives
15. The Etiopathogenesis of Autoimmunity
16. Overview of Immune Tolerance Strategies
17. Death Receptor-Mediated Apoptosis and Lymphocyte Homeostasis
18. Shifting Paradigms in Peripheral Tolerance
19. Dendritic Cells Control the Balance between Tolerance and Autoimmunity
20. CD4+ Τ Regulatory Cells and Modulation of Undesired Immune Responses
21. Major Histocompatibility Complex and Autoimmune Disease
22. Analyzing Complex Polygenic Traits: The Role of Non-HLA Genes in the Susceptibility to Autoimmune Disorders
23. Drug-Induced Autoimmunity
24. Evidence for a Role of Infections in the Activation of Autoreactive Τ Cells and the Pathogenesis of Autoimmunity
25. Molecular Analysis of Immunity
26. Immune Reconstitution after Hematopoietic Stem Cell Transplantation
27. Historical Perspective and Rationale of HSCT for Autoimmune Diseases
28. High-Dose Immune Suppression without Hematopoietic Stem Cells for Autoimmune Diseases
29. Autologous Stem Cell Transplantation in Animal Models of Autoimmune Diseases
30. Allogeneic Hemopoietic Stem Cell Transplantation in Animal Models of Autoimmune Disease
31. Mobilization and Conditioning Regimens in Stem Cell Transplant for Autoimmune Diseases
32. Infection in the Hematopoeitic Stem Cell Transplant Recipient with Autoimmune Disease
33. Immunological Aspects of Multiple Sclerosis with Emphasis on the Potential Use of Autologous Hemopoietic Stem Cell Transplantation
34. Axonal Injury and Disease Progression in Multiple Sclerosis
35. Monitoring Disease Activity in Multiple Sclerosis
36. Intense Immunosuppression Followed by Autologous Stem Cell Transplantation in Severe Multiple Sclerosis Cases: MRI and Clinical Data
37. Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Finding Equipoise
38. Molecular and Cellular Pathogenesis of Systemic Lupus Erythematosus
39. Definition, Classification, Activity and Damage Indices in Systemic Lupus Erythematosus
40. Lupus Nephritis
41. Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus
42. Treatment of Rheumatoid Arthritis
43. Haemopoietic Stem Cell Transplantation for Rheumatoid Arthritis—World Experience and Future Trials
44. Autologous Stem Cell Transplantation for Refractory Juvenile Idiopathic Arthritis (JIA)
45. Immunology of Scleroderma
46. Hematopoietic Stem Cell Transplantation for Systemic Sclerosis
47. High-Dose Immunosuppressive Chemotherapy with Autologous Stem Cell Support for Chronic Autoimmune Thrombocytopenia
48. High-Dose Chemotherapy with Haematopoietic Stem Cell Transplantation in Primary Systemic Vasculitis, Behcet’s Disease and Sjogren’s Syndrome
49. Hematopoietic Stem Cell Transplantation in the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy
50. Hematopoietic Stem Cell Therapy for Patients with Refractory Myasthenia Gravis
51. Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Bullous Skin Disorders
52. Idiopathic Inflammatory Myositis
53. Hematopoietic Stem Cell Transplantation as Treatment for Type 1 Diabetes
54. Autologous Hematopoietic Stem Cell Transplantation for Crohn’s Disease
55. Bronchial Asthma and Idiopathic Pulmonary Fibrosis as Potential Targets for Hematopoietic Stem Cell Transplantation
56. Autologous Stem Cell Transplantation in Relapsing Polychondritis
57. Allogeneic Hematopoietic Stem Cell Transplantation for Autoimmune Diseases

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