Systems Biomedicine Concepts and Perspectives 1st Edition by Edison Liu, Douglas Lauffenburger 9780123725509 012372550X
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Product details:
ISBN 10: 012372550X
ISBN 13: 9780123725509
Author: Edison T. Liu, Douglas A. Lauffenburger
Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon.
* Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine
* Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable
* Includes a thorough discussion of the applications of quantitative principles to biomedical problems
Table of contents:
SECTION I: FOUNDATIONS OF SYSTEMS BIOLOGY
Chapter 1. Foundations for Systems Biomedicine: An Introduction
Chapter 2. Genomic Technologies for Systems Biology
Chapter 3. Proteomics Technologies
Chapter 4. Cellular Regulatory Networks
Chapter 5. The Interface of MicroRNAs and Transcription Factor Networks
Chapter 6. Protein Networks in Integrin-mediated Adhesions
Chapter 7. Systems Biology and Stem Cell Biology
SECTION II: COMPUTATIONAL MODELING IN SYSTEMS BIOLOGY
Chapter 8. Computational Challenges in Systems Biology
Chapter 9. High-level Modeling of Biological Networks
Chapter 10. Systems Analysis for Systems Biology
Chapter 11. The Virtual Cell Project
Chapter 12. Software Tools for Systems Biology
SECTION III: APPLICATIONS OF SYSTEMS BIOLOGY
Chapter 13. Physiome Mark-up Languages for Systems Biology: Model Modularization and Re-use
Chapter 14. Systems Approaches to Developmental Patterning
Chapter 15. Applications of Immunologic Modeling to Drug Discovery and Development
Chapter 16. Systems Pharmacology in Cancer
Chapter 17. Systems Biology in Drug Discovery: Using Predictive Biomedicine to Guide Development
Chapter 18. Quantitative Biology and Clinical Trials: A Perspective
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Tags: Edison Liu, Douglas Lauffenburger, Systems, Biomedicine