The Causes of Epilepsy Common and Uncommon Causes in Adults and Children 1st Edition by Simon Shorvon, Frederick Andermann, Renzo Guerrini 0521114470 9780521114479
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ISBN 10: 0521114470
ISBN 13: 9780521114479
Author: Simon D. Shorvon, Frederick Andermann, Renzo Guerrini
Causation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into four etiological categories: idiopathic, symptomatic, cryptogenic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in each etiology, including its epidemiology, clinical features and prognosis, and any specific aspects of treatment. The book is a comprehensive reference work, a catalogue of all important causes of epilepsy, and a clinical tool for all clinicians dealing with patients who have epilepsy. It is aimed at epileptologists and neurologists and provides a distillation of knowledge in a form that is helpful in the clinical setting.
Table of contents:
Section 1 Introduction
1 Historical introduction: the causes of epilepsy in the pre-molecular era (1860–1960)
2 The etiological classification of epilepsy
3 Epileptogenesis in idiopathic epilepsy
4 Mechanisms of epileptogenesis in symptomatic epilepsy
Section 2 Idiopathic epilepsy
5 Introduction to the concept of genetic epilepsy
6 The genetic contribution to epilepsy: the known and missing heritability
Subsection 2.1 Pure epilepsies due to single-gene disorders
7 Benign familial neonatal seizures
8 Autosomal dominant nocturnal frontal lobe epilepsy
9 Genetic epilepsy with febrile seizures plus
10 Severe myoclonic epilepsy of infancy or Dravet syndrome
11 Benign adult familial myoclonic epilepsy
Subsection 2.2 Pure epilepsies with presumed complex inheritance
12 Idiopathic generalized epilepsies
13 Benign partial epilepsies of childhood
Section 3 Symptomatic epilepsy
14 Introduction to the concept of symptomatic epilepsy
Subsection 3.1 Epilepsy syndromes
15 West syndrome and Lennox–Gastaut syndrome
Subsection 3.2 Progressive myoclonic epilepsies
16 Unverricht–Lundborg disease
17 Dentato-rubro-pallido-luysian atrophy
18 Lafora body disease
19 Mitochondrial cytopathies
20 Neuronal ceroid lipofuscinoses
21 Sialidosis and Gaucher disease
22 Action myoclonus–renal failure syndrome
23 Progressive myoclonus epilepsies: other rare causes
Subsection 3.3 Neurocutaneous syndromes
24 Tuberous sclerosis complex
25 Neurofibromatoses
26 Sturge–Weber syndrome
27 Other neurocutaneous syndromes
Subsection 3.4 Other single-gene disorders with epilepsy as a prominent symptom
28 Angelman syndrome
29 Lysosomal disorders and Menkes syndrome
30 Neuroacanthocytosis
31 Organic acid, amino acids, and peroxisomal disorders
32 Porphyria
33 Pyridoxine-dependent epilepsy
34 Rett syndrome and MECP2 and CDKL5 genotypes
35 Urea cycle disorders
36 Wilson disease
37 Disorders of cobalamin and folate metabolism
38 Other single-gene disorders
Subsection 3.5 Disorders of chromosome structure
39 Down syndrome
40 Fragile X syndrome
41 4p (Wolf–Hirschhorn) syndrome
42 Inverted duplicated chromosome 15 (isodicentric chromosome 15)
43 Ring chromosome 20
Subsection 3.6 Developmental anomalies of cerebral structure (cortical dysplasias)
44 Hemimegalencephaly
45 Focal cortical dysplasia and related variants
46 Agyria–pachygyria band spectrum
47 Agenesis of the corpus callosum
48 Polymicrogyria and schizencephaly
49 Periventricular nodular heterotopia
50 Microcephaly
51 Arachnoid cysts
52 Malformations of human cerebral cortex
Subsection 3.7 Hippocampal sclerosis and prenatal and perinatal injury
53 Hippocampal sclerosis
54 Neonatal seizures and postneonatal epilepsy – causes
55 Cerebral palsy
56 Vaccination and immunization
Subsection 3.8 Cerebral trauma
57 Open head injury
58 Closed head injury
59 De novo epilepsy after neurosurgery
60 Epilepsy after epilepsy surgery
61 Non-accidental brain injury
Subsection 3.9 Cerebral tumor
62 Glioma
63 Ganglioglioma, dysembryoplastic neuroepithelial tumor, and related tumors
64 Hypothalamic hamartoma and gelastic epilepsy
65 Meningioma
66 Metastatic disease
Subsection 3.10 Cerebral infection
67 Viral encephalitis
68 Bacterial meningitis and focal suppurative intracranial infections in children
69 Bacterial meningitis and pyogenic abscess in adults
70 Malaria
71 Neurocysticercosis
72 Other parasitic diseases
73 Tuberculosis
74 HIV infection
75 Emerging and less common central nervous system viral encephalitides
Subsection 3.11 Cerebrovascular disease
76 Cerebral hemorrhage
77 Cerebral infarction and occult degenerative cerebrovascular disease
78 Arteriovenous malformations
79 Cavernous malformations
80 Other vascular disorders
Subsection 3.12 Cerebral immunological disorders
81 Rasmussen encephalitis and related conditions
82 Systemic lupus erythematosus and other collagen vascular diseases
83 Inflammatory and immunological diseases of the nervous system
Subsection 3.13 Other cerebral disorders
84 Psychiatric disorders
85 Multiple sclerosis and other acquired demyelinating diseases
86 Hydrocephalus and porencephaly
87 Alzheimer disease and other neurodegenerative diseases
Section 4 Provoked epilepsies
88 Introduction to the concept of provoked epilepsy
Subsection 4.1 Precipitating factors
89 Fever
90 The menstrual cycle and catamenial epilepsy
91 Sleep
92 Metabolic and endocrine-induced seizures
93 Electrolyte and sugar disturbances
94 Drug-induced seizures
95 Alcohol- and toxin-induced seizures
Subsection 4.2 Reflex seizures
96 How reflex mechanisms cause epilepsy
97 Visual stimuli, photosensitivity, and photosensitive epilepsy
98 Startle-induced (and other sensory-induced) epilepsy
99 Primary reading epilepsy
100 Auditory-induced epilepsy
101 Focal reflex seizures – with emphasis on seizures triggered by eating
102 Hot-water epilepsy
103 Reflex epilepsy with higher-level processing
Section 5 Status epilepticus
104 Introduction – how status epilepticus is caused
105 Causes of status epilepticus in children
106 The causes of convulsive status epilepticus in adults
107 Uncommon causes of status epilepticus
108 Causes of non-convulsive status epilepticus in adults
109 Causes of epilepsia partialis continua
110 Afterword
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Tags: Simon Shorvon, Frederick Andermann, Renzo Guerrini, Common