The Comprehensive Sourcebook of Bacterial Protein Toxins 3rd Edition by Joseph Alouf, Michel Popoff 9780120884452 0080456987
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Product details:
ISBN 10: 0080456987
ISBN 13: 9780120884452
Author: Joseph E. Alouf, Michel R. Popoff
This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.
* Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France
* 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology
* Includes the major toxins of both basic and clinical interest are described in depth
* Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology
* Evolutionary and functional aspects of bacterial toxins evaluated and summarized
* Toxin applications in cell biology presented
* Therapy (cancer therapy, dystonias) discussed
* Vaccines (native and genetically engineered vaccines) featured
* Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
Table of contents:
1 A 116-year story of bacterial protein toxins (1888-2004): from “diphtheritic poison” to molecular
SECTION I BASIC GENOMIC AND PHYSIOLOGICAL ASPECTS OF BACTERIAL PROTEIN TOXINS
2 Evolutionary aspects of toxin-producing bacteria
3 Mobile genetic elements and pathogenicity islands encoding bacterial toxins
4 Regulation systems of toxin expression
5 Toxin secretion systems
6 Toxin receptors
7 Translocation of bacterial protein toxins into the cytosol
8 Intracellular trafficking of bacterial and plant protein toxins
9 Bacterial toxins and virulence factors targeting the actin cytoskeleton and intercellular junction
10 Bacterial toxins and mitochondria
11 Toxins activating Rho GTPases and exploiting the cellular ubiquitin/ proteasome machineries
SECTION II BACTERIAL PROTEIN TOXINS ACTING IN THE INTRACELLULAR COMPARTMENT OF EUKARYOTIC CELLS
12 Molecular, functional, and evolutionary aspects of ADP-ribosylating toxins
13 Diphtheria toxin
14 Pseudomonas aeruginosa toxins
15 Vibrio cholerae and Escherichia coli thermolabile enterotoxin
16 Bordetella protein toxins
17 The Shiga toxins: properties and action on cells
18 Bacillus anthracis toxins
19 Attack of the nervous system by clostridial toxins: physical findings, cellular and molecular act
20 Uptake and transport of clostridium neurotoxins
21 Large clostridial cytotoxins modifying small GTPases
22 Pasteurella multocida toxin
23 Cytolethal distending toxins
24 Helicobacter pylori vacuolating toxin
25 Escherichia coli heat-stable enterotoxin b
SECTION III TOXINS ACTING ON THE SURFACE OF TARGET CELLS (EXCEPT SUPERANTIGENS)
26 Paradigms and classification of bacterial membrane-damaging toxins
27 Membrane-damaging and cytotoxic phospholipases
28 Bacteroides fragilis toxins
29 Structure and mode of action of RTX toxins
30 Genetics and phylogeny of RTX cytolysins
31 The family of two-component cytolysins of Serratia and other bacteria
32 Alpha-helix and beta-barrel pore-forming toxins (leucocidins, alpha-, gamma-, and delta-cytolysin
33 Aerolysin and related Aeromonas toxins
34 Clostridium septicum pore-forming α-toxin
35 Clostridium perfringens ε-toxin
36 Repertoire and general features of the family of cholesterol- dependent cytolysins
37 Comparative three-dimensional structure of cholesterol-dependent cytolysins
38 Perfringolysin O and intermedilysin: mechanisms of pore formation by the cholesterol-dependent cy
39 Pneumolysin: structure, function, and role in disease
40 Listeriolysin
41 Enterococcus faecalis cytolysin toxin
42 Streptolysin S: one of the most potent and elusive of all bacterial toxins
43 The group B streptococcal β-hemolysin/cytolysin
44 Hemolysins of vibrio cholerae and other vibrio species
45 Clostridium perfringens enterotoxin
46 Bacillus cereus enterotoxins, bi- and tri-component cytolysins, and other hemolysins
47 Uropathogenic Escherichia coli cytolysins
48 Escherichia coli, Vibrio, and Yersinia species heat-stable enterotoxins
SECTION IV SUPERANTIGENIC TOXINS
49 What are superantigens?
50 Staphylococcal superantigens and the diseases they cause
51 Streptococcal superantigenic toxins
52 The superantigenic toxin of Yersinia pseudotuberculosis
53 Comparative three-dimensional structure of bacterial superantigenic toxins
SECTION V CLINICAL, IMMUNOLOGICAL ASPECTS AND APPLICATIONS OF BACTERIAL PROTEIN TOXINS IN CELL BIOLO
54 Induction and modulation of inflammatory networks by bacterial protein toxins
55 Clostridial toxins in the pathogenesis of gas gangrene
56 Staphylococcal exfoliative toxins
57 Bacterial toxins as food poisons
58 Medical applications of botulinum neurotoxins
59 Toxins as tools
60 Engineering of bacterial toxins for research and medicine
61 Engineered bacterial toxin vaccines and adjuvants
62 Bacterial protein toxins as biological weapons
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