Virulence Mechanisms of Bacterial Pathogens 4th Edition by Nancy Cornick, F Chris Minion, Michael J Wannemuehler, Kim A Brogden ISBN 1555814697 9781555815851

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ISBN 10: 1555814697 
ISBN 13: 9781555815851
Author: Nancy Cornick, F Chris Minion, Michael J Wannemuehler, Kim A Brogden

Virulence Mechanisms of Bacterial Pathogens 4th Table of contents:

Part I: Fundamental Principles of Bacterial Pathogenesis

• Chapter 1: Introduction to Bacterial Pathogenesis and Virulence
  • Defining Pathogenicity, Virulence, and Commensalism
  • The Host-Pathogen Interaction: A Dynamic Relationship
  • Evolution of Bacterial Virulence: Genetic and Environmental Factors
  • Koch’s Postulates and Molecular Koch’s Postulates
• Chapter 2: Adhesion and Colonization
  • Mechanisms of Adherence: Pili (Fimbriae), Non-Fimbrial Adhesins
  • Host Receptors and Specificity
  • Colonization Strategies: Biofilms, Tissue Tropism
• Chapter 3: Invasion of Host Cells and Tissues
  • Invasion Mechanisms: Zipper and Trigger Mechanisms
  • Intracellular Survival Strategies: Phagosome Escape, Replication in Vacuoles
  • Crossing Host Barriers (e.g., Blood-Brain Barrier, Intestinal Epithelium)
• Chapter 4: Bacterial Toxins: Types and Mechanisms of Action
  • Exotoxins: AB Toxins, Membrane-Damaging Toxins, Superantigens
  • Endotoxin (LPS): Structure, Activity, and Immune Response
  • Modulation of Host Cell Signaling Pathways
  • Role of Toxins in Specific Diseases

Part II: Evasion and Modulation of Host Defenses

• Chapter 5: Evasion of the Innate Immune System
  • Capsules and Slime Layers: Antiphagocytic Properties
  • Modulation of Complement Activation
  • Resistance to Antimicrobial Peptides
  • Interference with Phagolysosome Maturation
• Chapter 6: Evasion of the Adaptive Immune System
  • Antigenic Variation and Phase Variation
  • Modulation of Antigen Presentation
  • Induction of Apoptosis in Immune Cells
  • Subversion of Cytokine and Chemokine Networks
• Chapter 7: Iron Acquisition and Nutrient Scavenging
  • The Iron Withholding Response of the Host
  • Bacterial Siderophores and Iron Uptake Systems
  • Hemophores and Utilization of Heme Iron
  • Acquisition of Other Essential Nutrients (e.g., Zinc, Manganese)
• Chapter 8: Biofilms in Pathogenesis
  • Formation and Structure of Bacterial Biofilms
  • Role of Biofilms in Chronic Infections
  • Biofilm-Mediated Antibiotic Resistance
  • Quorum Sensing in Biofilm Development

Part III: Regulation of Virulence and Host Response

• Chapter 9: Global Regulatory Networks and Quorum Sensing
  • Two-Component Signal Transduction Systems
  • Quorum Sensing: Autoinducers and Coordinated Virulence Gene Expression
  • Stress Responses and Their Impact on Virulence
  • Small RNAs in Virulence Regulation
• Chapter 10: Secretion Systems: Delivery of Virulence Factors
  • Type I, II, and III Secretion Systems
  • Type IV Secretion Systems (e.g., for DNA transfer)
  • Type V and VI Secretion Systems
  • Effector Proteins and Their Host Targets
• Chapter 11: Host-Pathogen Crosstalk and Immune Evasion
  • Pattern Recognition Receptors (PRRs) and PAMPs
  • Immune Suppression and Dysregulation by Pathogens
  • Host Cell Manipulation: Apoptosis, Necroptosis, Pyroptosis
  • The Commensal Microbiota and Pathogen Colonization Resistance

Part IV: Specific Bacterial Pathogens and Their Virulence Strategies

• Chapter 12: Staphylococcus aureus: Superbug Virulence
  • Adhesins, Toxins (e.g., Panton-Valentine Leukocidin, Alpha-Toxin)
  • Immune Evasion Strategies (e.g., Protein A, Coagulase)
  • MRSA and Antibiotic Resistance Mechanisms
• Chapter 13: Streptococcus pyogenes: Necrotizing Fasciitis and Beyond
  • M Protein, Streptolysins, Pyrogenic Exotoxins
  • Hyaluronic Acid Capsule and Biofilm Formation
  • Immune System Subversion
• Chapter 14: Escherichia coli (Pathogenic Strains)
  • Enterotoxigenic E. coli (ETEC), Enterohemorrhagic E. coli (EHEC), Uropathogenic E. coli (UPEC)
  • Adhesins, Toxins (e.g., Shiga toxin, LT/ST toxins)
  • Intimin and Type III Secretion Systems
• Chapter 15: Salmonella and Shigella Species: Intracellular Pathogens
  • Invasion of Epithelial Cells
  • Salmonella Pathogenicity Islands (SPIs) and Type III Secretion Systems
  • Intracellular Survival and Replication
• Chapter 16: Pseudomonas aeruginosa: Chronic Infections and Opportunism
  • Biofilms, Exotoxins (e.g., Exotoxin A), Elastase
  • Quorum Sensing Regulation
  • Cystic Fibrosis Lung Infections
• Chapter 17: Mycobacterium tuberculosis: Surviving in Macrophages
  • Unique Cell Wall Structure
  • Immune Evasion within Phagosomes
  • Latency and Reactivation
• Chapter 18: Other Important Bacterial Pathogens
  • Neisseria gonorrhoeae and Neisseria meningitidis (Antigenic Variation)
  • Clostridium difficile (Toxins A and B, Spore Formation)
  • Vibrio cholerae (Cholera Toxin, ToxR Regulation)
  • Helicobacter pylori (Urease, CagA, VacA)
  • Spirochetes (Treponema pallidum, Borrelia burgdorferi)

Part V: Diagnostics, Therapeutics, and Future Directions

• Chapter 19: Diagnostics Based on Virulence Mechanisms
  • Detection of Specific Toxins or Virulence Genes
  • Molecular Diagnostics for Pathogen Identification
  • Serological Assays for Immune Response to Virulence Factors
• Chapter 20: Targeting Virulence: Novel Therapeutic Strategies
  • Anti-Virulence Drugs: Inhibiting Adhesion, Toxin Production, Quorum Sensing
  • Phage Therapy and Lytic Enzymes
  • Host-Directed Therapies
• Chapter 21: Vaccines and Prophylaxis
  • Traditional Vaccine Approaches
  • Vaccines Targeting Virulence Factors
  • Challenges in Vaccine Development for Complex Pathogens
• Chapter 22: The Future of Pathogen Virulence Research
  • Genomics, Proteomics, and Metabolomics in Virulence Studies
  • Single-Cell Analysis and In Vivo Imaging
  • Impact of the Microbiome on Pathogen Virulence
  • Emerging Pathogens and Antimicrobial Resistance

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Tags: Nancy Cornick, F Chris Minion, Michael J Wannemuehler, Kim A Brogden, Mechanisms