Virulence Mechanisms of Bacterial Pathogens 4th Edition by Nancy Cornick, F Chris Minion, Michael J Wannemuehler, Kim A Brogden – Ebook PDF Instant Download/Delivery: 1555814697, 9781555815851
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ISBN 10: 1555814697
ISBN 13: 9781555815851
Author: Nancy Cornick, F Chris Minion, Michael J Wannemuehler, Kim A Brogden
Virulence Mechanisms of Bacterial Pathogens 4th Table of contents:
Part I: Fundamental Principles of Bacterial Pathogenesis
- Chapter 1: Introduction to Bacterial Pathogenesis and Virulence
- Defining Pathogenicity, Virulence, and Commensalism
- The Host-Pathogen Interaction: A Dynamic Relationship
- Evolution of Bacterial Virulence: Genetic and Environmental Factors
- Koch’s Postulates and Molecular Koch’s Postulates
- Chapter 2: Adhesion and Colonization
- Mechanisms of Adherence: Pili (Fimbriae), Non-Fimbrial Adhesins
- Host Receptors and Specificity
- Colonization Strategies: Biofilms, Tissue Tropism
- Chapter 3: Invasion of Host Cells and Tissues
- Invasion Mechanisms: Zipper and Trigger Mechanisms
- Intracellular Survival Strategies: Phagosome Escape, Replication in Vacuoles
- Crossing Host Barriers (e.g., Blood-Brain Barrier, Intestinal Epithelium)
- Chapter 4: Bacterial Toxins: Types and Mechanisms of Action
- Exotoxins: AB Toxins, Membrane-Damaging Toxins, Superantigens
- Endotoxin (LPS): Structure, Activity, and Immune Response
- Modulation of Host Cell Signaling Pathways
- Role of Toxins in Specific Diseases
Part II: Evasion and Modulation of Host Defenses
- Chapter 5: Evasion of the Innate Immune System
- Capsules and Slime Layers: Antiphagocytic Properties
- Modulation of Complement Activation
- Resistance to Antimicrobial Peptides
- Interference with Phagolysosome Maturation
- Chapter 6: Evasion of the Adaptive Immune System
- Antigenic Variation and Phase Variation
- Modulation of Antigen Presentation
- Induction of Apoptosis in Immune Cells
- Subversion of Cytokine and Chemokine Networks
- Chapter 7: Iron Acquisition and Nutrient Scavenging
- The Iron Withholding Response of the Host
- Bacterial Siderophores and Iron Uptake Systems
- Hemophores and Utilization of Heme Iron
- Acquisition of Other Essential Nutrients (e.g., Zinc, Manganese)
- Chapter 8: Biofilms in Pathogenesis
- Formation and Structure of Bacterial Biofilms
- Role of Biofilms in Chronic Infections
- Biofilm-Mediated Antibiotic Resistance
- Quorum Sensing in Biofilm Development
Part III: Regulation of Virulence and Host Response
- Chapter 9: Global Regulatory Networks and Quorum Sensing
- Two-Component Signal Transduction Systems
- Quorum Sensing: Autoinducers and Coordinated Virulence Gene Expression
- Stress Responses and Their Impact on Virulence
- Small RNAs in Virulence Regulation
- Chapter 10: Secretion Systems: Delivery of Virulence Factors
- Type I, II, and III Secretion Systems
- Type IV Secretion Systems (e.g., for DNA transfer)
- Type V and VI Secretion Systems
- Effector Proteins and Their Host Targets
- Chapter 11: Host-Pathogen Crosstalk and Immune Evasion
- Pattern Recognition Receptors (PRRs) and PAMPs
- Immune Suppression and Dysregulation by Pathogens
- Host Cell Manipulation: Apoptosis, Necroptosis, Pyroptosis
- The Commensal Microbiota and Pathogen Colonization Resistance
Part IV: Specific Bacterial Pathogens and Their Virulence Strategies
- Chapter 12: Staphylococcus aureus: Superbug Virulence
- Adhesins, Toxins (e.g., Panton-Valentine Leukocidin, Alpha-Toxin)
- Immune Evasion Strategies (e.g., Protein A, Coagulase)
- MRSA and Antibiotic Resistance Mechanisms
- Chapter 13: Streptococcus pyogenes: Necrotizing Fasciitis and Beyond
- M Protein, Streptolysins, Pyrogenic Exotoxins
- Hyaluronic Acid Capsule and Biofilm Formation
- Immune System Subversion
- Chapter 14: Escherichia coli (Pathogenic Strains)
- Enterotoxigenic E. coli (ETEC), Enterohemorrhagic E. coli (EHEC), Uropathogenic E. coli (UPEC)
- Adhesins, Toxins (e.g., Shiga toxin, LT/ST toxins)
- Intimin and Type III Secretion Systems
- Chapter 15: Salmonella and Shigella Species: Intracellular Pathogens
- Invasion of Epithelial Cells
- Salmonella Pathogenicity Islands (SPIs) and Type III Secretion Systems
- Intracellular Survival and Replication
- Chapter 16: Pseudomonas aeruginosa: Chronic Infections and Opportunism
- Biofilms, Exotoxins (e.g., Exotoxin A), Elastase
- Quorum Sensing Regulation
- Cystic Fibrosis Lung Infections
- Chapter 17: Mycobacterium tuberculosis: Surviving in Macrophages
- Unique Cell Wall Structure
- Immune Evasion within Phagosomes
- Latency and Reactivation
- Chapter 18: Other Important Bacterial Pathogens
- Neisseria gonorrhoeae and Neisseria meningitidis (Antigenic Variation)
- Clostridium difficile (Toxins A and B, Spore Formation)
- Vibrio cholerae (Cholera Toxin, ToxR Regulation)
- Helicobacter pylori (Urease, CagA, VacA)
- Spirochetes (Treponema pallidum, Borrelia burgdorferi)
Part V: Diagnostics, Therapeutics, and Future Directions
- Chapter 19: Diagnostics Based on Virulence Mechanisms
- Detection of Specific Toxins or Virulence Genes
- Molecular Diagnostics for Pathogen Identification
- Serological Assays for Immune Response to Virulence Factors
- Chapter 20: Targeting Virulence: Novel Therapeutic Strategies
- Anti-Virulence Drugs: Inhibiting Adhesion, Toxin Production, Quorum Sensing
- Phage Therapy and Lytic Enzymes
- Host-Directed Therapies
- Chapter 21: Vaccines and Prophylaxis
- Traditional Vaccine Approaches
- Vaccines Targeting Virulence Factors
- Challenges in Vaccine Development for Complex Pathogens
- Chapter 22: The Future of Pathogen Virulence Research
- Genomics, Proteomics, and Metabolomics in Virulence Studies
- Single-Cell Analysis and In Vivo Imaging
- Impact of the Microbiome on Pathogen Virulence
- Emerging Pathogens and Antimicrobial Resistance
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Tags: Nancy Cornick, F Chris Minion, Michael J Wannemuehler, Kim A Brogden, Mechanisms