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Vitamin D Physiology Molecular Biology and Clinical Applications 2nd Edition by Michael Holick 160327300X 9781603273008

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Vitamin D Physiology Molecular Biology and Clinical Applications 2nd Edition Michael F. Holick Phd Digital Instant Download

Author(s): Michael F. Holick PHD, MD (auth.), Michael F. Holick (eds.)
ISBN(s): 9781603273008, 160327300X
Edition: 2
File Details: PDF, 15.10 MB
Year: 2010
Language: english
SKU: EB-2044136 Category: Tags: , ,

Vitamin D Physiology Molecular Biology and Clinical Applications 2nd Edition by Michael Holick – Ebook PDF Instant Download/Delivery: 160327300X, 9781603273008

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Product details:

ISBN 10: 160327300X

ISBN 13: 9781603273008

Author: Michael F. Holick

In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 1, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Presented in a newly affordable softcover format this volume contains Parts IV through VII of the previously published hardcover text. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaining good bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and thesequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D’s molecular mechanism of action on the cell membrane and nucleus.

Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 2 is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiency pandemic and its clinical implications for health and disease.

Table of contents:

Vitamin D and Health: Evolution, Biologic Functions, and Recommended Dietary Intakes for Vitamin D
Photobiology of Vitamin D
The Functional Metabolism and Molecular Biology of Vitamin D Action
Metabolism and Catabolism of Vitamin D, Its Metabolites and Clinically Relevant Analogs
The Molecular Biology of the Vitamin D Receptor
VDR and RXR Subcellular Trafficking
Mechanism of Action of 1,25-Dihydroxyvitamin D₃ on Intestinal Calcium Absorption and Renal Calcium Transport
Biological and Molecular Effects of Vitamin D on Bone
Biological and Molecular Effects of Vitamin D on the Kidney
Vitamin D and the Parathyroids
Diversity of Vitamin D Target Genes
Front Matter
Extrarenal Synthesis of 1,25-Dihydroxyvitamin D and Its Health Implications
Vitamin D and the Innate Immunity
Vitamin D and Colon Cancer
Mechanisms of Resistance to Vitamin D Action in Human Cancer Cells
Vitamin D and the Brain: A Neuropsychiatric Perspective
Vitamin D Modulation of Adipocyte Function
Front Matter
Determinants of Vitamin D Intake
25-Hydroxyvitamin D Assays and Their Clinical Utility
Health Disparities and Vitamin D
Front Matter
Vitamin D Deficiency in Canada
Vitamin D Deficiency and Its Health Consequences in Northern Europe
Vitamin D Deficiency and Consequences for the Health of People in Mediterranean Countries
Vitamin D Deficiency in the Middle East and Its Health Consequences
Vitamin D Deficiency in the Middle East and Its Health Consequences for Adults
Vitamin D Deficiency and Its Health Consequences in Africa
Vitamin D Deficiency and Its Health Consequences in India
Vitamin D Deficiency, Rickets, and Fluorosis in India
Vitamin D in Asia
Vitamin D Deficiency and Its Health Consequences in New Zealand
Toxicity of Vitamin D
Front Matter
Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences
Vitamin D Deficiency in Children and Its Health Consequences
Dietary Calcium Deficiency and Rickets
Vitamin D in Fracture Prevention and Muscle Function and Fall Prevention
Inherited Defects of Vitamin D Metabolism
Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets (HVDRR)
Receptor-Independent Vitamin D Resistance in Subhuman and Human Primates
25-Hydroxyvitamin D-1α-Hydroxylase: Studies in Mouse Models and Implications for Human Disease
Front Matter
The Health Benefits of Solar Irradiance and Vitamin D / Vitamin D and the Consequences of Their Deprivation
Front Matter
Vitamin D Status, Solar Radiation and Cancer Prognosis
The Epidemiology of Vitamin D and Cancer Risk
Vitamin D Deficiency and the Epidemiology of Prostate Cancer
Vitamin D for Cancer Prevention and Survival
The Anti-cancer Effect of Vitamin D: What Do the Randomized Trials Show?
Sunlight, Skin Cancer, and Vitamin D
Front Matter
Vitamin D and the Risk of Type 1 Diabetes
Vitamin D and Multiple Sclerosis
Vitamin D and Type 2 Diabetes
Role of Vitamin D for Cardiovascular Health
Vitamin D, Renin, and Blood Pressure
Role of Vitamin D and Vitamin D Analogs for Bone Health and Survival in Chronic Kidney Disease
Role of Vitamin D and Ultraviolet Radiation in Chronic Kidney Disease
Role of Vitamin D in Rheumatoid Arthritis
Vitamin D, Respiratory Infections, and Obstructive Airway Diseases
Front Matter
Treatment of Immunomediated Diseases by Vitamin D Analogs
Clinical Utility of 1,25-Dihydroxyvitamin D₃ and Its Analogues for the Treatment of Psoriasis
Affinity Alkylating Vitamin D Analogs as Molecular Probes and Therapeutic Agents
Anti-inflammatory Activity of Calcitriol That Contributes to Its Therapeutic and Chemopreventive Effects in Prostate Cancer

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Tags: Michael Holick, Vitamin D, Physiology, Molecular