Von Willebrand Disease Basic and Clinical Aspects 1st Edition by Augusto Federici, Christine Lee, Erik Berntorp, David Lillicrap, Robert Montgomery 9781405195126 1405195126

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Product details:

ISBN 10: 1405195126

ISBN 13: 9781405195126

Author: Augusto B. Federici, Christine A. Lee, Erik E. Berntorp, David Lillicrap, Robert R. Montgomery

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease.

This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding.

Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy.

Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.

Table of contents:

1. Historical perspective on von Willebrand disease
   Erik Berntorp and Margareta Blombäck

2. Biosynthesis and organization of von Willebrand factor
   Sandra L. Haberichter

3. von Willebrand factor structure and function
   Robert R. Montgomery and Sandra L. Haberichter

4. Modulation of von Willebrand factor by ADAMTS13
   Jennifer Barr and David Motto

5. Animal models in von Willebrand disease
   Cécile V. Denis, Olivier D. Christophe and Peter J. Lenting

6. Classification of von Willebrand disease
   Javier Batlle, Almudena Pérez-Rodríguez and María Fernanda López-Fernández

7. The epidemiology of von Willebrand disease
   Giancarlo Castaman and Francesco Rodeghiero

8. Clinical aspects of von Willebrand disease: bleeding history
   Paula D. James and Alberto Tosetto

9. Laboratory diagnosis of von Willebrand disease: the phenotype
   Ulrich Budde and Emmanuel J. Favaloro

10. Molecular diagnosis of von Willebrand disease: the genotype
    Anne C. Goodeve and Reinhard Schneppenheim

11. Clinical, laboratory, and molecular markers of type 1 von Willebrand disease
    David Lillicrap, Francesco Rodeghiero, and Ian Peake

12. Clinical, laboratory, and molecular markers of type 2 von Willebrand disease
    Dominique Meyer, Edith Fressinaud, and Claudine Mazurier

13. Clinical, laboratory, and molecular markers of type 3 von Willebrand disease
    Luciano Baronciani, Augusto B. Federici, and Jeroen C.J. Eikenboom

14. Pediatric aspects of von Willebrand disease
    Jorge Di Paola and Thomas Abshire

15. Women with von Willebrand disease
    Christine A. Lee, Rezan A. Kadir, and Peter A. Kouides

16. On the use of desmopressin in von Willebrand disease
    Stefan Lethagen, Augusto B. Federici, and Giancarlo Castaman

17. The use of plasma-derived concentrates
    Pier Mannuccio Mannucci and Massimo Franchini

18. Prophylaxis in von Willebrand disease
    Erik Berntorp

19. Pathophysiology, epidemiology, diagnosis, and treatment of acquired von Willebrand syndrome
    Ulrich Budde, Augusto B. Federici and Jacob H. Rand

20. Gene therapy for von Willebrand disease
    Marinee K.L. Chuah, Inge Petrus, and Thierry Vanden Driessche

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Tags: Augusto Federici, Christine Lee, Erik Berntorp, Willebrand