Wnt Signaling in Embryonic Development 1st Edition by Sergei Y Sokol ISBN 0444528741 9780444528742

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Product details: 

ISBN 10: 0444528741

ISBN 13: 9780444528742

Author: Sergei Y. Sokol 

(signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling. Written by specialists in the field, these chapters cover different levels of signaling, including: ligands, receptors, cytoplasmic and nuclear components of the pathway. This book discusses a number of model systems including mice, Drosophila, Xenopus, zebrafish, C. elegans, and mammalian cells. Together, these chapters review the available knowledge and will fill gaps in our understanding of this interesting network of cell signaling processes.

* Includes two parts devoted to the canonical (beta-catenin dependent) and non-canonical branches of Wnt signalling to the cytoskeleton
* Offers insight to large genomic data that are now available for the analysis of Wnt gene targets
* Discusses regulators of the cytoskeleton such as small GTPAses of the Rho family, jun-N-terminal kinases and other MAP kinases, and proteins involved in the generation of cell polarity

Table of contents: 

Chapter 1: Wnt/beta-catenin-mediated transcriptional regulation
1. Introduction
2. The TCF family as mediators of Wnt/beta-catenin signaling
3. The “Off state”: Repression of Wnt targets in the absence of signaling
4. The “On State” in the nucleus; Arm/beta-catenin triggers the switch
5. beta-Catenin-mediated gene repression
6. Switching off signaling: A nuclear role for the destruction complex
7. Concluding remarks
References
Chapter 2: Wnt signaling and the establishment of cell polarity
1. Wnt-signaling pathways
2. Apical-basal and Planar Cell Polarity
3. Regulation of apical-basal polarity by Wnt signaling
4. PCP signaling in the Drosophila wing
5. PCP signaling in the Drosophila eye
6. PCP signaling is conserved in mammalian epithelium
7. Noncanonical Wnt signaling and polarized cell movements
8. Wnt signaling and asymmetric cell division
9. A new model system for PCP
10. Future directions
References
Chapter 3: Wnt signaling in C. elegans: New insights into the regulation of POP-1/TCF-mediated activ
1. Introduction
2. Wnt signaling in C. elegans: Pathway components
3. A canonical Wnt pathway regulates Hox gene expression
4. Wnt/MAPK signaling
5. P2/EMS signaling: Spindle orientation and endoderm induction
6. T cell polarity
7. Z1/4 polarity: Axis determination in the somatic gonad
8. Multiple mechanisms regulate POP-1 transcriptional activity
References
Chapter 4: The Wnt-signaling pathways in mammalian patterning and morphogenesis
1. Introduction
2. The canonical Wnt pathway in mammalian patterning
3. The noncanonical Wnt pathway in mammalian morphogenesis
4. Summary
References
Chapter 5: Cell migration under control of Wnt-signaling in the vertebrate embryo
1. Introduction
2. Modes of cell migration in the vertebrate embryo
3. Cell migration in the early embryo
4. Neuronal migration
5. Cell migration in eye development
6. Heart development
7. Conclusions
Acknowledgments
References
Chapter 6: Multiple roles for Wnt signaling in the development of the vertebrate neural crest
1. Introduction
2. Wnt signals and neural crest induction
3. Expression of Wnt ligands and receptors
4. Gain- and loss-of-function studies
5. Wnt signals and a hierarchy of regulatory steps
6. Wnt signals in delamination and the onset of migration
7. Wnt signals and neural crest cell fate diversification
8. Conclusions and future directions
Acknowledgments
References
Chapter 7: Wnt pathways in angiogenesis
1. Angiogenesis: A brief introduction
2. Wnts and Frizzleds in vascular biology
3. Wnt signaling and pathological angiogenesis
4. Norrin, a new player in the field
5. Wnt regulation of angiogenesis
6. Current perspectives

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Sergei Y Sokol,Signaling,Embryonic